Document Detail


Retinoic acid receptor-related orphan receptor α-induced activation of adenosine monophosphate-activated protein kinase results in attenuation of hepatic steatosis.
MedLine Citation:
PMID:  22183856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: We found that RORα induced activation of AMPK and inhibition of the lipogenic function of LXRα, which may be key phenomena that provide the beneficial effects of RORα against hepatic steatosis.
Authors:
Eun-Jin Kim; Young-Sil Yoon; Suckchang Hong; Ho-Young Son; Tae-Young Na; Min-Ho Lee; Hyun-Jin Kang; Jinyoung Park; Won-Jea Cho; Sang-Gun Kim; Seung-Hoi Koo; Hyeung-geun Park; Mi-Ock Lee
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  55     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-20     Completed Date:  2012-06-19     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1379-88     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Affiliation:
College of Pharmacy, Seoul National University, Seoul, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adenosine Monophosphate / metabolism*
Animals
Cells, Cultured / metabolism
Diet, High-Fat
Disease Models, Animal
Enzyme Activation
Fatty Liver / enzymology*,  pathology
Hepatocytes / drug effects,  metabolism
Lipid Metabolism / physiology
Mice
Mice, Inbred Strains
Orphan Nuclear Receptors / metabolism*
Protein Kinases / metabolism*
Random Allocation
Receptors, Retinoic Acid / metabolism*
Reference Values
Chemical
Reg. No./Substance:
0/Orphan Nuclear Receptors; 0/Receptors, Retinoic Acid; 0/liver X receptor; 0/retinoic acid receptor alpha; 61-19-8/Adenosine Monophosphate; EC 2.7.-/Protein Kinases; EC 2.7.1.-/AMP-activated protein kinase kinase
Comments/Corrections
Erratum In:
Hepatology. 2013 Jan;57(1):423

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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