| RNase L downmodulation of the RNA-binding protein, HuR, and cellular growth. | |
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MedLine Citation:
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PMID: 19252527 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ribonuclease L (RNase L) is an intracellular enzyme that is vital in innate immunity, but also is a tumor suppressor candidate. Here, we show that overexpression of RNase L decreases cellular growth and downmodulates the RNA-binding protein, HuR, a regulator of cell-cycle progression and tumorigenesis. The effect is temporal, occurring in specific cell-cycle phases and correlated with the cytoplasmic localization of RNase L. Both cellular growth and HuR were increased in RNASEL-null mouse fibroblast lines when compared to wild-type cells. Moreover, the stability of HuR mRNA was enhanced in RNASEL-null cells. The HuR 3' untranslated region (UTR), which harbors U-rich and adenylate-uridylate-rich elements, was potently responsive to RNase L when compared to control 3' UTR. Our results may offer a new explanation to the tumor suppressor function of RNase L. |
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Authors:
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W Al-Ahmadi; L Al-Haj; F A Al-Mohanna; R H Silverman; K S A Khabar |
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Publication Detail:
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Type: Journal Article Date: 2009-03-02 |
Journal Detail:
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Title: Oncogene Volume: 28 ISSN: 1476-5594 ISO Abbreviation: Oncogene Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-16 Completed Date: 2009-04-28 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 8711562 Medline TA: Oncogene Country: England |
Other Details:
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Languages: eng Pagination: 1782-91 Citation Subset: IM |
Affiliation:
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Program in BioMolecular Research, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3' Untranslated Regions
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physiology Animals Antigens, Surface / genetics Cell Cycle Cell Proliferation Down-Regulation Endoribonucleases / physiology* HeLa Cells Humans Mice Mice, Inbred C57BL RNA, Messenger / analysis RNA-Binding Proteins / antagonists & inhibitors*, genetics |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA044059/CA/NCI NIH HHS; R01 CA044059-26/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/3' Untranslated Regions; 0/Antigens, Surface; 0/ELAVL1 protein, human; 0/RNA, Messenger; 0/RNA-Binding Proteins; EC 3.1.-/Endoribonucleases; EC 3.1.26.-/2-5A-dependent ribonuclease |
| Comments/Corrections | |
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