| RNAi targeting EZH2 inhibits tumor growth and liver metastasis of pancreatic cancer in vivo. | |
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MedLine Citation:
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PMID: 20684863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The function of EZH2 in tumorigenesis and liver metastasis of pancreatic cancer has never been elucidated in vivo. EZH2 was overexpressed in pancreatic carcinomas and its overexpression was associated with tumor differentiation and pT status. Suppression of EZH2 caused a significant growth inhibition of pancreatic cancer cells in vitro and markedly diminished their tumorigenicity in vivo. Knock-down of EZH2 inhibited liver metastasis of pancreatic cancer in vivo. EZH2 has a crucial role in tumor growth and liver metastasis of pancreatic cancer. |
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Authors:
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Yangchao Chen; Dan Xie; Wing Yin Li; Chi Man Cheung; Hong Yao; Ching Yu Chan; Chu-yan Chan; Fang-Ping Xu; Yan-Hui Liu; Joseph J Y Sung; Hsiang-fu Kung |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-06-01 |
Journal Detail:
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Title: Cancer letters Volume: 297 ISSN: 1872-7980 ISO Abbreviation: Cancer Lett. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 109-16 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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The Chinese University of Hong Kong, Shatin, Hong Kong. b110796@mailserv.cuhk.edu.hk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Carcinoma, Pancreatic Ductal / genetics, metabolism, secondary, therapy* Cell Differentiation Cell Line, Tumor DNA-Binding Proteins / genetics*, metabolism Female Gene Therapy / methods* Humans Liver Neoplasms / genetics, metabolism, prevention & control*, secondary Male Mice Mice, Nude Middle Aged Neoplasm Staging Pancreatic Neoplasms / genetics, metabolism, pathology, therapy* RNA Interference* Time Factors Transcription Factors / genetics*, metabolism Transfection Tumor Burden* Up-Regulation Xenograft Model Antitumor Assays |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/EZH2 protein, human; 0/Transcription Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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