| RNAi, heterochromatin and the cell cycle. | |
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MedLine Citation:
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PMID: 18778867 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For many decades after its initial characterization, heterochromatin was considered to be transcriptionally inert, but newer work indicates that this highly condensed chromosomal material is transcribed, and rapidly silenced, by an orchestrated sequence of events directed by RNA interference (RNAi). Recent studies shed light on the timely assembly and inheritance of heterochromatin within a short period during the cell cycle, thereby providing an explanation for how 'silent' heterochromatin can be transcribed during the S phase of the cell cycle. Together, these findings suggest a model of RNAi-directed epigenetic inheritance. |
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Authors:
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Anna Kloc; Robert Martienssen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2008-09-06 |
Journal Detail:
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Title: Trends in genetics : TIG Volume: 24 ISSN: 0168-9525 ISO Abbreviation: Trends Genet. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-17 Completed Date: 2009-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8507085 Medline TA: Trends Genet Country: England |
Other Details:
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Languages: eng Pagination: 511-7 Citation Subset: IM |
Affiliation:
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Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / genetics* DNA Transposable Elements / physiology Epigenesis, Genetic / physiology Heterochromatin / physiology* Humans Models, Biological RNA Interference / physiology* RNA, Small Interfering / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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GM076396/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Transposable Elements; 0/Heterochromatin; 0/RNA, Small Interfering |
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