Document Detail


An RNA transport system in Candida albicans regulates hyphal morphology and invasive growth.
MedLine Citation:
PMID:  19779551     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Localization of specific mRNAs is an important mechanism through which cells achieve polarity and direct asymmetric growth. Based on a framework established in Saccharomyces cerevisiae, we describe a She3-dependent RNA transport system in Candida albicans, a fungal pathogen of humans that grows as both budding (yeast) and filamentous (hyphal and pseudohyphal) forms. We identify a set of 40 mRNAs that are selectively transported to the buds of yeast-form cells and to the tips of hyphae, and we show that many of the genes encoded by these mRNAs contribute to hyphal development, as does the transport system itself. Although the basic system of mRNA transport is conserved between S. cerevisiae and C. albicans, we find that the cargo mRNAs have diverged considerably, implying that specific mRNAs can easily move in and out of transport control over evolutionary timescales. The differences in mRNA cargos likely reflect the distinct selective pressures acting on the two species.
Authors:
Sarah L Elson; Suzanne M Noble; Norma V Solis; Scott G Filler; Alexander D Johnson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-09-25
Journal Detail:
Title:  PLoS genetics     Volume:  5     ISSN:  1553-7404     ISO Abbreviation:  PLoS Genet.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-09-25     Completed Date:  2010-02-05     Revised Date:  2014-02-12    
Medline Journal Info:
Nlm Unique ID:  101239074     Medline TA:  PLoS Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e1000664     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Actins / metabolism
Candida albicans / cytology,  genetics,  growth & development*,  metabolism*
Epithelial Cells / microbiology,  pathology
Fungal Proteins / genetics,  metabolism
Gene Expression Regulation, Fungal
Genes, Fungal
Humans
Hyphae / cytology*,  growth & development*,  metabolism
RNA Transport*
RNA, Fungal / metabolism*
RNA, Messenger / genetics,  metabolism
Saccharomyces cerevisiae / genetics
Grant Support
ID/Acronym/Agency:
R01 AI49187/AI/NIAID NIH HHS; R01 DE017088/DE/NIDCR NIH HHS; R01 DE017088/DE/NIDCR NIH HHS
Chemical
Reg. No./Substance:
0/Actins; 0/Fungal Proteins; 0/RNA, Fungal; 0/RNA, Messenger
Comments/Corrections
Erratum In:
PLoS Genet. 2009 Oct;5(10). doi: 10.1371/annotation/17eb3a67-8f49-454b-acbf-5ff2872c27ff

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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