| RNA: prebiotic product, or biotic invention? | |
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MedLine Citation:
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PMID: 17443885 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Spectacular advances in structural and molecular biology have added support to the 'RNA world' hypothesis, and provide a mandate for chemistry to explain how RNA might have been generated prebiotically on the early earth. Difficulties in achieving a prebiotically plausible synthesis of RNA, however, have led many to ponder the question posed in the title of this paper. Herein, we review recent experimental work on the assembly of potential RNA precursors, focusing on methods for stereoselective C-C bond construction by aldolisation and related processes. This chemistry is presented in the context of a broader picture of the potential constitutional self-assembly of RNA. Finally, the relative accessibility of RNA and alternative nucleic acids is considered. |
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Authors:
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Carole Anastasi; Fabien F Buchet; Michael A Crowe; Alastair L Parkes; Matthew W Powner; James M Smith; John D Sutherland |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Chemistry & biodiversity Volume: 4 ISSN: 1612-1880 ISO Abbreviation: Chem. Biodivers. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-25 Completed Date: 2007-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101197449 Medline TA: Chem Biodivers Country: Switzerland |
Other Details:
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Languages: eng Pagination: 721-39 Citation Subset: IM |
Affiliation:
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School of Chemistry, University of Manchester, Oxford Road, Manchester, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biogenesis* Models, Molecular Nucleic Acid Conformation Oligoribonucleotides / chemistry RNA / biosynthesis, chemistry* Ribonucleotides / chemistry Ribose |
| Chemical | |
Reg. No./Substance:
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0/Oligoribonucleotides; 0/Ribonucleotides; 50-69-1/Ribose; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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