Document Detail

RNA polymerase: chromosome domain boundary maker and regulator of supercoil density.
MedLine Citation:
PMID:  25460807     Owner:  NLM     Status:  Publisher    
Most bacterial chromosomes and plasmids are covalently closed circular molecules that are maintained in a dynamic supercoiled state. Average supercoil density differs significantly between Escherichia coli and Salmonella. Two related questions are: What protein(s) create supercoil domain boundaries in a bacterial chromosome? and How is supercoil density regulated in different bacterial species? RNA polymerase plays pivotal roles in both of these topological phenomena.
N Patrick Higgins
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Publication Detail:
Type:  REVIEW     Date:  2014-11-1
Journal Detail:
Title:  Current opinion in microbiology     Volume:  22C     ISSN:  1879-0364     ISO Abbreviation:  Curr. Opin. Microbiol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  9815056     Medline TA:  Curr Opin Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  138-143     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier Ltd.
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