Document Detail


RNA polymerase II carboxy-terminal domain with multiple connections.
MedLine Citation:
PMID:  17603278     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The largest subunit of eukaryotic RNA polymerase II contains a unique domain at its carboxy-terminus, which is referred to as the carboxy-terminal domain (CTD). The CTD is made up of an evolutionarily conserved heptapeptide repeat (YSPTSPS). Over the past decade, there has been increasing attention on the role of the CTD in transcription regulation in the view of mRNA processing and chromatin remodeling. This paper provides a brief overview of the recent progress in the dynamic changes in CTD phosphorylation and its role in integrating multiple nuclear events.
Authors:
Eun-Jung Cho
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Experimental & molecular medicine     Volume:  39     ISSN:  1226-3613     ISO Abbreviation:  Exp. Mol. Med.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-02     Completed Date:  2007-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607880     Medline TA:  Exp Mol Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  247-54     Citation Subset:  IM    
Affiliation:
College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea. echo@skku.edu
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Motifs
Amino Acid Sequence
Animals
Chromatin / physiology*
Chromatin Assembly and Disassembly
Conserved Sequence
Histones / metabolism
Humans
Isomerism
Phosphorylation
Protein Structure, Tertiary
RNA Polymerase II / chemistry,  physiology*
RNA, Messenger / metabolism
Transcription, Genetic
Chemical
Reg. No./Substance:
0/Chromatin; 0/Histones; 0/RNA, Messenger; EC 2.7.7.-/RNA Polymerase II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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