| RNA polymerase II carboxy-terminal domain with multiple connections. | |
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MedLine Citation:
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PMID: 17603278 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The largest subunit of eukaryotic RNA polymerase II contains a unique domain at its carboxy-terminus, which is referred to as the carboxy-terminal domain (CTD). The CTD is made up of an evolutionarily conserved heptapeptide repeat (YSPTSPS). Over the past decade, there has been increasing attention on the role of the CTD in transcription regulation in the view of mRNA processing and chromatin remodeling. This paper provides a brief overview of the recent progress in the dynamic changes in CTD phosphorylation and its role in integrating multiple nuclear events. |
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Authors:
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Eun-Jung Cho |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Experimental & molecular medicine Volume: 39 ISSN: 1226-3613 ISO Abbreviation: Exp. Mol. Med. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-02 Completed Date: 2007-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607880 Medline TA: Exp Mol Med Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 247-54 Citation Subset: IM |
Affiliation:
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College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea. echo@skku.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Motifs Amino Acid Sequence Animals Chromatin / physiology* Chromatin Assembly and Disassembly Conserved Sequence Histones / metabolism Humans Isomerism Phosphorylation Protein Structure, Tertiary RNA Polymerase II / chemistry, physiology* RNA, Messenger / metabolism Transcription, Genetic |
| Chemical | |
Reg. No./Substance:
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0/Chromatin; 0/Histones; 0/RNA, Messenger; EC 2.7.7.-/RNA Polymerase II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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