Document Detail


RNA-mediated regulation in Gram-positive pathogens: an overview punctuated with examples from the group A Streptococcus.
MedLine Citation:
PMID:  25091277     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
RNA-based mechanisms of regulation represent a ubiquitous class of regulators that are associated with diverse processes including nutrient sensing, stress response, modulation of horizontal gene transfer, and virulence factor expression. While better studied in Gram-negative bacteria, the literature is replete with examples of the importance of RNA-mediated regulatory mechanisms to the virulence and fitness of Gram-positives. Regulatory RNAs are classified as cis-acting, e.g. riboswitches, which modulate the transcription, translation, or stability of co-transcribed RNA, or trans-acting, e.g. small regulatory RNAs, which target separate mRNAs or proteins. The group A Streptococcus (GAS, Streptococcus pyogenes) is a Gram-positive bacterial pathogen from which several regulatory RNA mechanisms have been characterized. The study of RNA-mediated regulation in GAS has uncovered novel concepts with respect to how small regulatory RNAs may positively regulate target mRNA stability, and to how CRISPR RNAs are processed from longer precursors. This review provides an overview of RNA-mediated regulation in Gram-positive bacteria, and is highlighted with specific examples from GAS research. The key roles that these systems play in regulating bacterial virulence are discussed and future perspectives outlined.
Authors:
Eric W Miller; Tram N Cao; Kathryn J Pflughoeft; Paul Sumby
Related Documents :
8634147 - A large variety of alternatively spliced and differentially expressed mrnas are encoded...
25025957 - Brca1 mrna levels following a 4-6-week intervention with oral 3,3'-diindolylmethane.
24367017 - Methyl jasmonate-elicited transcriptional responses and pentacyclic triterpene biosynth...
23478317 - Study of the response regulator rrp1 reveals its regulatory role in chitobiose utilizat...
10886247 - Differential regulation of nitric oxide synthase isoforms in experimental acute chagasi...
15654837 - Involvement of th1 cells and heat shock protein 60 in the pathogenesis of intestinal be...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-8-5
Journal Detail:
Title:  Molecular microbiology     Volume:  -     ISSN:  1365-2958     ISO Abbreviation:  Mol. Microbiol.     Publication Date:  2014 Aug 
Date Detail:
Created Date:  2014-8-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8712028     Medline TA:  Mol Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Impact of rli87 gene deletion on response of Listeria monocytogenes to environmental stress.
Next Document:  Light-induced spin-state switching in the mixed crystal series of the 2D coordination network {[Zn1-...