| RNA-mediated pathogenesis in fragile X-associated disorders. | |
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MedLine Citation:
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PMID: 19631721 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Noncoding RNAs play important and diverse regulatory roles throughout the genome and make major contributions to disease pathogenesis. The FMR1 gene is involved in three different syndromes: fragile X syndrome (FXS), primary ovarian insufficiency (POI), and fragile X-associated tremor/ataxia syndrome (FXTAS) in older patients. Noncoding RNAs have been implicated in the molecular pathogenesis of both FXS and FXTAS. Here we will review our current knowledge on the role(s) of noncoding RNAs in FXS and FXTAS, particularly the role of the microRNA pathway in FXS and the role of noncoding riboCGG (rCGG) repeat in FXTAS. |
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Authors:
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Huiping Tan; He Li; Peng Jin |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review Date: 2009-07-23 |
Journal Detail:
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Title: Neuroscience letters Volume: 466 ISSN: 1872-7972 ISO Abbreviation: Neurosci. Lett. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-10-26 Completed Date: 2010-01-05 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 103-8 Citation Subset: IM |
Affiliation:
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Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Fragile X Mental Retardation Protein
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genetics,
metabolism Fragile X Syndrome* / complications, genetics, pathology Humans RNA, Untranslated* / genetics, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 MH076090-04/MH/NIMH NIH HHS; R01 NS051630-04/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/FMR1 protein, human; 0/RNA, Untranslated; 139135-51-6/Fragile X Mental Retardation Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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