Document Detail


RNA interference trigger variants: getting the most out of RNA for RNA interference-based therapeutics.
MedLine Citation:
PMID:  22703279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The manifestation of RNA interference (RNAi)-based therapeutics lies in safe and successful delivery of small interfering RNAs (siRNAs), the molecular entity that triggers and guides sequence-specific degradation of target mRNAs. Optimizing the chemistry and structure of siRNAs to achieve maximum efficacy is an important parameter in the development of siRNA therapeutics. The RNAi protein machinery can tolerate a variety of non-canonical modifications made to siRNAs, each of which imparts advantageous properties. Here, we review these modifications to siRNAs in pre-clinical and clinical studies.
Authors:
Nicholas M Snead; John J Rossi
Related Documents :
10591629 - Ropporin, a sperm-specific binding protein of rhophilin, that is localized in the fibro...
15182189 - Structural characterization of fish egg vitelline envelope proteins by mass spectrometry.
22401549 - Small rna fragments in complex culture media cause alterations in protein profiles of t...
22736769 - Rapid uptake and degradation of cxcl12 depend on cxcr7 carboxyl-terminal serine/threoni...
1954029 - Analysis of protamines isolated from alcohol preserved epididymides.
22566209 - Novel system for in vivo biotinylation and its application to crab antimicrobial protei...
7713919 - Membrane expression and interactions of human transcobalamin ii receptor.
5276769 - The mechanism of protein synthesis activation after fertilization of sea urchin eggs.
12514139 - Arabidopsis tobamovirus multiplication (tom) 2 locus encodes a transmembrane protein th...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Nucleic acid therapeutics     Volume:  22     ISSN:  2159-3345     ISO Abbreviation:  Nucleic Acid Ther     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-06-18     Completed Date:  2012-10-22     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  101562758     Medline TA:  Nucleic Acid Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  139-46     Citation Subset:  IM    
Affiliation:
Department of Molecular and Cellular Biology and Irell and Manella Graduate School of Biological Sciences, Beckman Research Institute at City of Hope, Duarte, California 91010, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Clinical Trials as Topic
Humans
RNA Interference*
RNA, Small Interfering / administration & dosage,  therapeutic use*
Grant Support
ID/Acronym/Agency:
R01A1042552//PHS HHS; R01HL074704/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Small Interfering
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mechanism of inhibition of the glutamate transporter EAAC1 by the conformationally constrained gluta...
Next Document:  Transcriptional silencing by hairpin RNAs complementary to a gene promoter.