| Is RNA interference involved in intrinsic antiviral immunity in mammals? | |
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MedLine Citation:
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PMID: 16715068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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RNA interference constitutes a key component of the innate immune response to viral infection in both plants and invertebrate animals and has been postulated to have a similar protective function in mammals. This perspective reviews the available data addressing whether RNA interference forms part of the mammalian innate immune response and concludes that the popular hypothesis in favor of that possibility remains far from proven and may not be valid. |
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Authors:
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Bryan R Cullen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Nature immunology Volume: 7 ISSN: 1529-2908 ISO Abbreviation: Nat. Immunol. Publication Date: 2006 Jun |
Date Detail:
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Created Date: 2006-05-22 Completed Date: 2006-08-08 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100941354 Medline TA: Nat Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 563-7 Citation Subset: IM |
Affiliation:
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Center for Virology and Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, North Carolina 27710, USA. culle002@mc.duke.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Immunity / genetics* MicroRNAs / genetics Nucleic Acid Conformation Plants / immunology, virology RNA Interference* Virus Diseases / immunology*, virology Viruses / genetics, immunology* |
| Grant Support | |
ID/Acronym/Agency:
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GM071408/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/MicroRNAs |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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