Document Detail


RNA interference in fungi: pathways, functions, and applications.
MedLine Citation:
PMID:  21724934     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Small RNA molecules of about 20 to 30 nucleotides function in gene regulation and genomic defense via conserved eukaryotic RNA interference (RNAi)-related pathways. The RNAi machinery consists of three core components: Dicer, Argonaute, and RNA-dependent RNA polymerase. In fungi, the RNAi-related pathways have three major functions: genomic defense, heterochromatin formation, and gene regulation. Studies of Schizosaccharomyces pombe and Neurospora, and other fungi have uncovered surprisingly diverse small RNA biogenesis pathways, suggesting that fungi utilize RNAi-related pathways in various cellular processes to adapt to different environmental conditions. These studies also provided important insights into how RNAi functions in eukaryotic systems in general. In this review, we will discuss our current understanding of the fungal RNAi-related pathways and their functions, with a focus on filamentous fungi. We will also discuss how RNAi can be used as a tool in fungal research.
Authors:
Yunkun Dang; Qiuying Yang; Zhihong Xue; Yi Liu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-07-01
Journal Detail:
Title:  Eukaryotic cell     Volume:  10     ISSN:  1535-9786     ISO Abbreviation:  Eukaryotic Cell     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-01     Completed Date:  2011-12-30     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  101130731     Medline TA:  Eukaryot Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1148-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Fungi / genetics*,  metabolism
Gene Expression Regulation
Gene Silencing
Genome
MicroRNAs / biosynthesis,  genetics*
Models, Genetic
Neurospora crassa / genetics,  metabolism
RNA Interference*
RNA Replicase / genetics
RNA, Fungal / biosynthesis,  genetics*
RNA, Small Interfering / biosynthesis,  genetics*
Schizosaccharomyces / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
R01 GM084283/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/MicroRNAs; 0/RNA, Fungal; 0/RNA, Small Interfering; EC 2.7.7.48/RNA Replicase
Comments/Corrections

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