Document Detail


The RNA-binding protein gene, hermes, is expressed at high levels in the developing heart.
MedLine Citation:
PMID:  10096065     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In a screen for novel sequences expressed during embryonic heart development we have isolated a gene which encodes a putative RNA-binding protein. This protein is a member of one of the largest families of RNA-binding proteins, the RRM (RNA Recognition Motif) family. The gene has been named hermes (for HEart, RRM Expressed Sequence). The hermes protein is 197-amino acids long and contains a single RRM domain. In situ hybridization analysis indicates that hermes is expressed at highest levels in the myocardium of the heart and to a lesser extent in the ganglion layer of the retina, the pronephros and epiphysis. Expression of hermes in each of these tissues begins at approximately the time of differentiation and is maintained throughout development. Analysis of the RNA expression of the hermes orthologues from chicken and mouse reveals that, like Xenopus, the most prominent tissue of expression is the developing heart. The sequence and expression pattern of hermes suggests a role in post-transcriptional regulation of heart development.
Authors:
W V Gerber; T A Yatskievych; P B Antin; K M Correia; R A Conlon; P A Krieg
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Mechanisms of development     Volume:  80     ISSN:  0925-4773     ISO Abbreviation:  Mech. Dev.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-06-15     Completed Date:  1999-06-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9101218     Medline TA:  Mech Dev     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  77-86     Citation Subset:  IM    
Affiliation:
Institute for Cell and Molecular Biology, University of Texas at Austin 78712, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AF107889;  AF129933;  AF148511
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MeSH Terms
Descriptor/Qualifier:
Amino Acid Sequence
Animals
Base Sequence
Blotting, Northern
Chick Embryo
Embryo, Mammalian / metabolism
Embryo, Nonmammalian / metabolism
Eye / metabolism
Gene Expression Regulation, Developmental
Gene Library
Heart / embryology*
Kidney / metabolism
Mice
Molecular Sequence Data
Multigene Family
Myocardium / metabolism
Protein Structure, Secondary
RNA-Binding Proteins / metabolism*
Sequence Homology, Amino Acid
Tissue Distribution
Xenopus / embryology
Xenopus Proteins*
Grant Support
ID/Acronym/Agency:
HL20220/HL/NHLBI NIH HHS; HL52746/HL/NHLBI NIH HHS; HL54133/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/RNA-Binding Proteins; 0/Rbpms protein, mouse; 0/Xenopus Proteins; 0/hermes protein, Xenopus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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