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RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours.
MedLine Citation:
PMID:  22034885     Owner:  NLM     Status:  In-Data-Review    
Xue D, Peng Y, Wang F, Allan R W & Cao D (2011) Histopathology59, 452-459 RNA-binding protein LIN28 is a sensitive marker of ovarian primitive germ cell tumours Aims:  LIN28 is an RNA-binding protein that has been detected in testicular germ cell tumours (GCTs), but its status in ovarian GCTs is unknown. The aim was to determine the immunohistochemical profile of LIN28 in ovarian GCTs. Methods and results:  Immunohistochemistry of LIN28 was performed in 110 primary and 11 metastatic ovarian GCTs. The percentage of tumour cells stained was scored as 0, 1+ (1-30% cells), 2+ (31-60%), 3+ (61-90%), and 4+ (>90%). To determine its specificity, we stained LIN28 in 119 non-GCTs, including 37 clear cell carcinomas. Strong 4+ LIN28 staining was seen in 4/4 (100%) gonadoblastomas, 7/7 (100%) embryonal carcinomas (ECs), and 41/41 (100%) yolk sac tumours (YSTs). Among 39 dysgerminomas, 4+ staining was seen in 37 and 3+ staining in two (strong in 37; mixed weak and strong in two). Twelve of 14 immature teratomas showed variable LIN28 staining (1+ to 4+) in the immature neuroepithelium (weak to strong staining), whereas mature teratomas, carcinoids, struma ovarii and strumal carcinoids were negative. Only 5/117 non-GCTs (1/37 clear cell carcinomas) showed weak to moderate 1-2+ staining. Conclusions:  LIN28 is a sensitive marker for gonadoblastomas, dysgerminomas, ECs, and YSTs. LIN28 can be used to distinguish them from non-GCTs.
Debin Xue; Yan Peng; Fenghua Wang; Robert W Allan; Dengfeng Cao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Histopathology     Volume:  59     ISSN:  1365-2559     ISO Abbreviation:  Histopathology     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-10-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704136     Medline TA:  Histopathology     Country:  England    
Other Details:
Languages:  eng     Pagination:  452-9     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Limited.
Department of Pathology, The Affiliated Hospital of Putian University, Putian, Fujian Department of Pathology, The University of Texas-Southwestern Medical Center, Dallas, TX, USA Department of Pathology, Guangzhou Women and Children's Medical Centre, Guangdong, China Department of Pathology, University of Florida, Gainesville, FL, USA Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
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