| RNA aptamers directed against oligosaccharides. | |
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MedLine Citation:
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PMID: 16594623 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nucleic acid molecules are designed to interact predominantly with proteins or complementary nucleic acids. Interaction of nucleic acids with carbohydrates, abundant constituents of glycoproteins and glycolipids, are not common in cells. Biomedical applications of nucleic acids targeted against oligosaccharides, which are involved in the function of receptors, immune answer, host interaction with invading infectious agents, and cancer metastasis, are feasible. In vitro selection of nucleic acids interacting with oligoand polysaccharides is a promising strategy to identify potential inhibitors of biochemical recognition processes in which carbohydrates are involved. Several RNA and DNA aptamers directed against carbohydrates have already been isolated and characterized. The results are summarized in this article, and an attempt is made to draw initial conclusions concerning the perspectives of the outlined approach. |
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Authors:
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M Sprinzl; M Milovnikova; C S Voertler |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Handbook of experimental pharmacology Volume: - ISSN: 0171-2004 ISO Abbreviation: Handb Exp Pharmacol Publication Date: 2006 |
Date Detail:
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Created Date: 2006-04-05 Completed Date: 2006-04-20 Revised Date: 2007-05-15 |
Medline Journal Info:
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Nlm Unique ID: 7902231 Medline TA: Handb Exp Pharmacol Country: Germany |
Other Details:
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Languages: eng Pagination: 327-40 Citation Subset: IM |
Affiliation:
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Laboratorium für Biochemie, Universität Bayreuth, 95440 Bayreuth, Germany. mathias.sprinzl@uni-bayreuth.de |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbohydrate Sequence Carbohydrates / antagonists & inhibitors Humans Molecular Sequence Data Oligosaccharides / antagonists & inhibitors* RNA / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Carbohydrates; 0/Oligosaccharides; 63231-63-0/RNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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