| RNA-Regulated TRA-1 nuclear export controls sexual fate. | |
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MedLine Citation:
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PMID: 11703944 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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TRA-1, a member of the GLI family of transcription factors, is required for C. elegans female development. We find that TRA-1 has a sex-specific distribution consistent with its role in female development: nuclear TRA-1 is higher in hermaphrodite intestines and in specific germline regions than in males. TRA-1 patterns rely on nuclear export since treatment with leptomycin B, a CRM1-dependent export inhibitor, increases nuclearTRA-1 in males. TRA-1 export requires TRA-1 binding to the tra-2 3' untranslated region (3' UTR), as disruption of binding increases nuclear TRA-1 and female development. Our data are consistent with coexport of a TRA-1/tra-2 mRNA complex reducing TRA-1 nuclear activity, and identify an interesting RNA-based mechanism for controlling transcriptional activity and cell fate determination. |
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Authors:
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S P Segal; L E Graves; J Verheyden; E B Goodwin |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental cell Volume: 1 ISSN: 1534-5807 ISO Abbreviation: Dev. Cell Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-11-14 Completed Date: 2001-12-07 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 101120028 Medline TA: Dev Cell Country: United States |
Other Details:
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Languages: eng Pagination: 539-51 Citation Subset: IM |
Affiliation:
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Northwestern University Medical School and Robert H. Lurie Cancer Center, Chicago, Illinois 60611, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3' Untranslated Regions
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metabolism Active Transport, Cell Nucleus / physiology Animals Caenorhabditis elegans Caenorhabditis elegans Proteins* Cytoplasm / metabolism DNA-Binding Proteins* Drosophila Proteins* Female Gene Expression Regulation, Developmental Helminth Proteins / genetics*, metabolism* Hermaphroditism Male Mutation / physiology Phenotype RNA, Messenger / metabolism Ribonucleoproteins / genetics, metabolism Sex Differentiation / physiology* Transcription Factors / genetics*, metabolism* Transcriptional Activation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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GM51836/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/3' Untranslated Regions; 0/Caenorhabditis elegans Proteins; 0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Helminth Proteins; 0/RNA, Messenger; 0/Ribonucleoproteins; 0/Transcription Factors; 0/tra-1 protein, C elegans; 0/tra2 protein, Drosophila |
| Comments/Corrections | |
Comment In:
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Dev Cell. 2004 Jun;6(6):740-2
[PMID:
15177019
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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