Document Detail

RNA-Regulated TRA-1 nuclear export controls sexual fate.
MedLine Citation:
PMID:  11703944     Owner:  NLM     Status:  MEDLINE    
TRA-1, a member of the GLI family of transcription factors, is required for C. elegans female development. We find that TRA-1 has a sex-specific distribution consistent with its role in female development: nuclear TRA-1 is higher in hermaphrodite intestines and in specific germline regions than in males. TRA-1 patterns rely on nuclear export since treatment with leptomycin B, a CRM1-dependent export inhibitor, increases nuclearTRA-1 in males. TRA-1 export requires TRA-1 binding to the tra-2 3' untranslated region (3' UTR), as disruption of binding increases nuclear TRA-1 and female development. Our data are consistent with coexport of a TRA-1/tra-2 mRNA complex reducing TRA-1 nuclear activity, and identify an interesting RNA-based mechanism for controlling transcriptional activity and cell fate determination.
S P Segal; L E Graves; J Verheyden; E B Goodwin
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Developmental cell     Volume:  1     ISSN:  1534-5807     ISO Abbreviation:  Dev. Cell     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-14     Completed Date:  2001-12-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-51     Citation Subset:  IM    
Northwestern University Medical School and Robert H. Lurie Cancer Center, Chicago, Illinois 60611, USA.
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MeSH Terms
3' Untranslated Regions / metabolism
Active Transport, Cell Nucleus / physiology
Caenorhabditis elegans
Caenorhabditis elegans Proteins*
Cytoplasm / metabolism
DNA-Binding Proteins*
Drosophila Proteins*
Gene Expression Regulation, Developmental
Helminth Proteins / genetics*,  metabolism*
Mutation / physiology
RNA, Messenger / metabolism
Ribonucleoproteins / genetics,  metabolism
Sex Differentiation / physiology*
Transcription Factors / genetics*,  metabolism*
Transcriptional Activation / physiology
Grant Support
Reg. No./Substance:
0/3' Untranslated Regions; 0/Caenorhabditis elegans Proteins; 0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/Helminth Proteins; 0/RNA, Messenger; 0/Ribonucleoproteins; 0/Transcription Factors; 0/tra-1 protein, C elegans; 0/tra2 protein, Drosophila
Comment In:
Dev Cell. 2004 Jun;6(6):740-2   [PMID:  15177019 ]

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