| The RNA Polymerase II Transcriptional Machinery and Its Epigenetic Context. | |
| | |
MedLine Citation:
|
PMID: 23150254 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
RNA polymerase II (Pol II) is the main engine that drives transcription of protein-encoding genes in eukaryotes. Despite its intrinsic subunit complexity, Pol II is subject to a host of factors that regulate the multistep transcription process. Indeed, the hallmark of the transcription cycle is the dynamic association of Pol II with initiation, elongation and other factors. In addition, Pol II transcription is regulated by a series of cofactors (coactivators and corepressors). Among these, the Mediator has emerged as one of the key regulatory factors for Pol II. Transcription by Pol II takes place in the context of chromatin, which is subject to numerous epigenetic modifications. This chapter mainly summarizes the various biochemical mechanisms that determine formation and function of a Pol II preinitiation complex (PIC) and those that affect its progress along the gene body (elongation). It further examines the various epigenetic modifications that the Pol II machinery encounters, especially in certain developmental contexts, and highlights newer evidence pointing to a likely close interplay between this machinery and factors responsible for the chromatin modifications. |
| | |
Authors:
|
Maria J Barrero; Sohail Malik |
Related Documents
:
|
11735124 - Nf-kappab activation for constitutive expression of vcam-1 and icam-1 on b lymphocytes ... 1284954 - Patterns of phenotypic expression of human junctional, gingival and reduced enamel epit... 23451824 - Modification of carotenoid levels by abscission agents and expression of carotenoid bio... 12901874 - Vitamin c supplementation in normal subjects reduces constitutive icam-1 expression. 10825574 - Regulation of the dual function tissue transglutaminase/galpha(h) during murine neuromu... 12857754 - Ccaat/enhancer-binding protein family members recruit the coactivator creb-binding prot... |
Publication Detail:
|
Type: JOURNAL ARTICLE |
Journal Detail:
|
Title: Sub-cellular biochemistry Volume: 61 ISSN: 0306-0225 ISO Abbreviation: Subcell. Biochem. Publication Date: 2013 |
Date Detail:
|
Created Date: 2012-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0316571 Medline TA: Subcell Biochem Country: - |
Other Details:
|
Languages: ENG Pagination: 237-259 Citation Subset: - |
Affiliation:
|
Center for Regenerative Medicine, Dr Aiguader 88, Barcelona, Spain, mjbarrero@cmrb.eu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Basic Mechanisms in RNA Polymerase I Transcription of the Ribosomal RNA Genes.
Next Document: RNA Polymerase III Transcription - Regulated by Chromatin Structure and Regulator of Nuclear Chromat...