Document Detail


RNA modifications: a mechanism that modulates gene expression.
MedLine Citation:
PMID:  20387139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Accuracy in the flow of genetic information from DNA to protein, or gene expression, is essential to the viability of an organisms. Pre-mRNA splicing and protein translation are two major steps in eukaryotic gene expression that necessitate the production of accurate gene products. Both processes occur in large complexes, consisting of both proteins and noncoding RNAs. Interestingly, the RNA components contain a large number of posttranscriptional modifications, including 2'-O-methylation and pseudouridylation, which are functionally important. In this chapter, we highlight the functional aspects of the modifications of spliceosomal snRNA and rRNA and provide a framework for understanding how posttranscriptional modifications are capable of influencing gene expression.
Authors:
John Karijolich; Athena Kantartzis; Yi-Tao Yu
Related Documents :
15867349 - Inactivation of the invasion inhibitory gene iip45 by alternative splicing in gliomas.
15566939 - Molecular cloning of the chicken st2 gene and a novel variant form of the st2 gene prod...
15020709 - Bioinformatical assay of human gene morbidity.
15049519 - Altered gene expression in the adult brain of fyn-deficient mice.
16022389 - Hypomorphic mutation in hnrnp u results in post-implantation lethality.
19690979 - Identification of a novel vimentin promoter and mrna isoform.
25171199 - Transcriptional regulation of cell cycle genes in response to abiotic stresses correlat...
22052999 - Silencing of gstp1, a prostate cancer prognostic gene, by the estrogen receptor-β and e...
9383159 - Pheromone-induced production of antimicrobial peptides in lactobacillus.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  629     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-06-29     Revised Date:  2014-09-07    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-19     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Base Sequence
Humans
Molecular Sequence Data
RNA Processing, Post-Transcriptional / genetics*
RNA Splicing / genetics
RNA, Ribosomal / chemistry,  genetics,  metabolism
RNA, Small Nuclear / chemistry,  genetics,  metabolism
Spliceosomes / metabolism
Grant Support
ID/Acronym/Agency:
GM068411/GM/NIGMS NIH HHS; GM62937/GM/NIGMS NIH HHS; R01 GM062937/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/RNA, Ribosomal; 0/RNA, Small Nuclear
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Combined quantitative analysis of attenuation corrected and non-corrected myocardial perfusion SPECT...
Next Document:  Quantitative analysis of RNA modifications.