Document Detail

RGD mounted on an L-proline scaffold.
MedLine Citation:
PMID:  15946844     Owner:  NLM     Status:  MEDLINE    
The construction of an L-proline scaffold that enforces a defined beta-turn loop for RGD is reported. A key feature was the use of SASRIN (super acid sensitive resin) that allowed solid-phase synthesis of the tetrapeptide. A HATU-induced cyclization of the sequence was successful, followed by a single acid-promoted deprotection of the final product.
Eric Enholm; Ashwin Bharadwaj
Related Documents :
8315854 - Immunoaffinity purification and characterization of a human liver-specific antigen.
7688734 - Two truncated forms of rat insulin receptor-related receptor.
23887624 - A bodipy aldoxime-based chemodosimeter for highly selective and rapid detection of hypo...
8901124 - Isolation and amino acid sequence of a molt-inhibiting hormone from the american crayfi...
5651894 - Fatty-acid composition of mycoplasma lipids: biomembrane with only 1 fatty acid.
12749914 - Degradation of arginine and other amino acids by butyrate-producing asaccharolytic anae...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  15     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-24     Completed Date:  2005-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  3470-1     Citation Subset:  IM    
Department of Chemistry, University of Florida, Gainesville, FL 32611, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Molecular Structure
Oligopeptides / chemical synthesis*,  chemistry
Proline / chemistry*
Reg. No./Substance:
0/Oligopeptides; 147-85-3/Proline; 99896-85-2/arginyl-glycyl-aspartic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depress...
Next Document:  4,4'-Dimethoxytrityl group derived from secondary alcohols: are they removed slowly under acidic con...