Document Detail


RGD mounted on an L-proline scaffold.
MedLine Citation:
PMID:  15946844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The construction of an L-proline scaffold that enforces a defined beta-turn loop for RGD is reported. A key feature was the use of SASRIN (super acid sensitive resin) that allowed solid-phase synthesis of the tetrapeptide. A HATU-induced cyclization of the sequence was successful, followed by a single acid-promoted deprotection of the final product.
Authors:
Eric Enholm; Ashwin Bharadwaj
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Bioorganic & medicinal chemistry letters     Volume:  15     ISSN:  0960-894X     ISO Abbreviation:  Bioorg. Med. Chem. Lett.     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-24     Completed Date:  2005-12-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9107377     Medline TA:  Bioorg Med Chem Lett     Country:  England    
Other Details:
Languages:  eng     Pagination:  3470-1     Citation Subset:  IM    
Affiliation:
Department of Chemistry, University of Florida, Gainesville, FL 32611, USA. enholm@chem.ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Cyclization
Molecular Structure
Oligopeptides / chemical synthesis*,  chemistry
Proline / chemistry*
Chemical
Reg. No./Substance:
0/Oligopeptides; 147-85-3/Proline; 99896-85-2/arginyl-glycyl-aspartic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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