Document Detail


RGD-based cell ligands for cell-targeted drug delivery act as potent trophic factors.
MedLine Citation:
PMID:  22841914     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
FROM THE CLINICAL EDITOR: This work focuses on RGD peptides, which are among the most commonly used tags for targeted drug delivery. They also promote protoneurite formation and expression of neuronal markers (MAP2) in model PC12 cells, which is an unexpected but relevant event in the functionalization of drugs and their nanocarriers.
Authors:
Joan Domingo-Espín; Valérie Petegnief; Núria de Vera; Oscar Conchillo-Solé; Paolo Saccardo; Ugutz Unzueta; Esther Vazquez; Juan Cedano; Luciana Negro; Xavier Daura; Hugo Peluffo; Anna M Planas; Antonio Villaverde; Neus Ferrer-Miralles
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-25
Journal Detail:
Title:  Nanomedicine : nanotechnology, biology, and medicine     Volume:  8     ISSN:  1549-9642     ISO Abbreviation:  Nanomedicine     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-04-03     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  101233142     Medline TA:  Nanomedicine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1263-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Institut de Biotecnologia i de Biomedicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
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MeSH Terms
Descriptor/Qualifier:
Binding Sites
Cell Differentiation
Cell Proliferation
Drug Delivery Systems
Humans
Integrins* / chemistry,  metabolism
Ligands
MAP Kinase Signaling System
Nanoparticles / chemistry*
Neurons / cytology,  metabolism
Oligopeptides / chemistry*
Peptides / chemistry*
Protein Binding
Signal Transduction
Chemical
Reg. No./Substance:
0/Integrins; 0/Ligands; 0/Oligopeptides; 0/Peptides; 99896-85-2/arginyl-glycyl-aspartic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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