Document Detail


RFX6 is needed for the development and maintenance of the β-cell phenotype.
MedLine Citation:
PMID:  21750414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RFX6 has recently been found to be essential for the development of the endocrine pancreas through studies in both humans and mice. Interestingly, this gene maintains a specific expression in the postnatal hormone producing cells of the pancreas. Moreover in humans, different types of diabetes mellitus affect obligate carriers of RFX6 mutations. Therefore, RFX6 appears to have a pivotal role in the maintenance of the phenotype of the β-cells in addition to their development. Extensive research is needed to specify this role and explore its significance in the efforts to treat diabetes with medications, or more importantly, through β-cell replacement.
Authors:
Nadine Taleb; Constantin Polychronakos
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Publication Detail:
Type:  Journal Article     Date:  2011-09-01
Journal Detail:
Title:  Islets     Volume:  3     ISSN:  1938-2022     ISO Abbreviation:  Islets     Publication Date:    2011 Sep-Oct
Date Detail:
Created Date:  2011-09-08     Completed Date:  2012-01-05     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495366     Medline TA:  Islets     Country:  United States    
Other Details:
Languages:  eng     Pagination:  291-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
DNA-Binding Proteins / genetics,  physiology*
Diabetes Mellitus / genetics,  physiopathology
Gene Expression Regulation, Developmental / physiology
Homozygote
Humans
Insulin-Secreting Cells / cytology*,  physiology*
Islets of Langerhans / cytology,  embryology*,  physiology
Mice
Phenotype
Transcription Factors / genetics,  physiology*
Chemical
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Rfx6 protein, human; 0/Rfx6 protein, mouse; 0/Transcription Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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