Document Detail


RFX6 is needed for the development and maintenance of the β-cell phenotype.
MedLine Citation:
PMID:  21750414     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
RFX6 has recently been found to be essential for the development of the endocrine pancreas through studies in both humans and mice. Interestingly, this gene maintains a specific expression in the postnatal hormone producing cells of the pancreas. Moreover in humans, different types of diabetes mellitus affect obligate carriers of RFX6 mutations. Therefore, RFX6 appears to have a pivotal role in the maintenance of the phenotype of the β-cells, in addition to their development. Extensive research is needed to specify this role and explore its significance in the efforts to treat diabetes with medications, or more importantly, through β-cell replacement.
Authors:
Nadine Taleb; Constantin Polychronakos
Related Documents :
21448984 - Differential effects of nicotine and tobacco smoke condensate on human annulus fibrosus...
1337994 - Expression of neuroendocrine and epithelial markers in an adherent subline derived from...
2709874 - Human acute lymphoblastic leukemia cell lines with characteristics of intraclonal varia...
1434794 - Differences in dna fingerprints of continuous leukemia-lymphoma cell lines from differe...
15668134 - Efficient species c hadv infectivity in plasmocytic cell lines using a clathrin-indepen...
12237444 - Various morphological aspects of escherichia coli lysis by two distinct rna bacteriopha...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-01
Journal Detail:
Title:  Islets     Volume:  3     ISSN:  1938-2022     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-7-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101495366     Medline TA:  Islets     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Departments of Pediatrics and Human Genetics; McGill University; Montreal, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Regulation of insulin secretion and reactive oxygen species production by free fatty acids in pancre...
Next Document:  Diabetes mellitus is associated with an increased expression of resistin in human pancreatic islet c...