| RFX6 is needed for the development and maintenance of the β-cell phenotype. | |
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MedLine Citation:
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PMID: 21750414 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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RFX6 has recently been found to be essential for the development of the endocrine pancreas through studies in both humans and mice. Interestingly, this gene maintains a specific expression in the postnatal hormone producing cells of the pancreas. Moreover in humans, different types of diabetes mellitus affect obligate carriers of RFX6 mutations. Therefore, RFX6 appears to have a pivotal role in the maintenance of the phenotype of the β-cells, in addition to their development. Extensive research is needed to specify this role and explore its significance in the efforts to treat diabetes with medications, or more importantly, through β-cell replacement. |
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Authors:
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Nadine Taleb; Constantin Polychronakos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-01 |
Journal Detail:
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Title: Islets Volume: 3 ISSN: 1938-2022 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-7-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101495366 Medline TA: Islets Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Departments of Pediatrics and Human Genetics; McGill University; Montreal, Quebec, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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