| RFLP analysis and allelic discrimination with real-time PCR using the human lactase persistence trait: A pair of molecular genetic investigations. | |
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MedLine Citation:
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PMID: 21567819 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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We describe here two open-ended laboratory investigations for an undergraduate laboratory course that uses students' DNA as templates for quantitative real-time PCR and for traditional PCR followed by RFLP analysis. Students are captivated by the immediacy of the application and the relevance of the genotypes and traits, lactase persistence or nonpersistence, under study. Concepts ranging from nucleotide polymorphisms to natural selection can be demonstrated and reinforced by these laboratories. Students have a high degree of success with the laboratories and both objective and self-assessments of student learning indicate that concepts and techniques are better understood following implementation of these laboratory investigations. |
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Authors:
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Kenneth M Weinlander; David J Hall; Elizabeth A De Stasio |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology Volume: 38 ISSN: 1539-3429 ISO Abbreviation: Biochem Mol Biol Educ Publication Date: 2010 May |
Date Detail:
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Created Date: 2011-05-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100970605 Medline TA: Biochem Mol Biol Educ Country: United States |
Other Details:
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Languages: eng Pagination: 167-71 Citation Subset: - |
Copyright Information:
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Copyright © 2010 International Union of Biochemistry and Molecular Biology, Inc. |
Affiliation:
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Biology Department, Lawrence University, Appleton, Wisconsin 54911. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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