| Review: Pathogen-induced inflammation at sites distant from oral infection: bacterial persistence and induction of cell-specific innate immune inflammatory pathways. | |
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MedLine Citation:
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PMID: 20883220 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A hallmark of infection with the gram-negative pathogen Porphyromonas gingivalis is the induction of a chronic inflammatory response. P. gingivalis induces a local chronic inflammatory response that results in oral inflammatory bone destruction, which manifests as periodontal disease. In addition to chronic inflammation at the initial site of infection, mounting evidence has accumulated supporting a role for P. gingivalis-mediated periodontal disease as a risk factor for several systemic diseases including, diabetes, preterm birth, stroke, and atherosclerotic cardiovascular disease. A growing number of in vitro studies have demonstrated that P. gingivalis infection stimulates cell activation commensurate with expected responses paralleling inflammatory atherosclerotic-type responses. Furthermore, various mouse models have been used to examine the ability of P. gingivalis to stimulate chronic inflammatory plaque accumulation and recent studies have pointed to a pivotal role for innate immune signaling via the Toll-like receptors in the chronic inflammation associated with P. gingivalis infection. In this review we discuss the pathogen and host cell specificity of these responses and discuss possible mechanisms by which this oral pathogen can induce and maintain a chronic state of inflammation at sites distant from oral infection. |
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Authors:
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C Hayashi; C V Gudino; F C Gibson; C A Genco |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Molecular oral microbiology Volume: 25 ISSN: 2041-1014 ISO Abbreviation: Mol Oral Microbiol Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-24 Revised Date: 2012-05-07 |
Medline Journal Info:
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Nlm Unique ID: 101524770 Medline TA: Mol Oral Microbiol Country: Denmark |
Other Details:
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Languages: eng Pagination: 305-16 Citation Subset: D |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Department of Medicine, Sections of Infectious Diseases, Boston University School of Medicine, Boston, MA 02118, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atherosclerosis / etiology*, immunology, microbiology Bacteroidaceae Infections / immunology* Chronic Periodontitis / complications*, immunology, microbiology Disease Models, Animal Endothelium, Vascular / microbiology Foam Cells / immunology Focal Infection, Dental / immunology*, microbiology* Humans Immunity, Cellular Immunity, Innate Mice Organ Specificity Porphyromonas gingivalis / immunology* Toll-Like Receptors / immunology |
| Grant Support | |
ID/Acronym/Agency:
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HL080387/HL/NHLBI NIH HHS; R01 HL080387-05/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Toll-Like Receptors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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