Document Detail

Gut hormones and the brain.
MedLine Citation:
PMID:  20923479     Owner:  NLM     Status:  MEDLINE    
The dialogue between gut hormone, bile acids, and the brain plays an important role in energy homeostasis and the onset of Type 2 diabetes mellitus (T2DM). The present review focuses on: (i) bile acid metabolism and the role of bile acids in the regulation of both glucose homeostasis and the control of hypercholesterolemia; (ii) the role of gut hormones in energy homeostasis; and (iii) translation of the pathophysiology of bile acids and gut hormones into clinical practice. Although definitive mechanisms of action of gut hormones and bile acids have not been elucidated completely, these concepts allow us to understand several pharmacological interventions in the treatment of T2DM. Results from further clinical studies with related therapies will help us determine the role of these treatments in the management of energy homeostasis.
Yifei Zhang; Guang Ning; Yehuda Handelsman; Zachary T Bloomgarden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of diabetes     Volume:  2     ISSN:  1753-0407     ISO Abbreviation:  J Diabetes     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-10-06     Completed Date:  2011-02-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504326     Medline TA:  J Diabetes     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  138-45     Citation Subset:  IM    
Copyright Information:
© 2010 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Blackwell Publishing Asia Pty Ltd.
Shanghai Clinical Center for Endocrine and Metabolic Diseases and Division of Endocrine and Metabolic Diseases of E-Institutes of Shanghai Universities, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
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MeSH Terms
Bile Acids and Salts / physiology
Brain / physiology*
Gastrointestinal Hormones / physiology*
Ghrelin / physiology
Glucose / metabolism
Hypercholesterolemia / prevention & control
Incretins / physiology
Leptin / physiology
Receptors, Cytoplasmic and Nuclear / physiology
Satiety Response / physiology*
Reg. No./Substance:
0/Bile Acids and Salts; 0/Gastrointestinal Hormones; 0/Ghrelin; 0/Incretins; 0/Leptin; 0/Receptors, Cytoplasmic and Nuclear; 50-99-7/Glucose

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