Document Detail


Capecitabine induced cardiotoxicity: a case report and review of literature.
MedLine Citation:
PMID:  22186341     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Capecitabine is an oral prodrug of 5-fluorouracil (5-FU) which is converted in tumor cells to 5-FU by the enzyme thymidine phosphorylase. Nowadays, it is being widely used into the management of colorectal, breast and head and neck cancers because of its oral route and its comparable efficacy with 5-FU. 5-FU induced cardiotoxicity (angina and myocardial infarction) has been reported the literature, but capecitabine induced cardiotoxicity is less reported event. We report a patient with diagnosis of locally advanced adenocarcinoma of rectum who developed symptomatic bradycardia and acute ischemia while receiving oral capecitabine 825mg/m(2) twice daily with preoperative radiation.
Authors:
Mutahar Ali Tunio; Altaf Hashmi; Muhammad Shoaib
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Pakistan journal of pharmaceutical sciences     Volume:  25     ISSN:  1011-601X     ISO Abbreviation:  Pak J Pharm Sci     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-21     Completed Date:  2012-03-08     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9426356     Medline TA:  Pak J Pharm Sci     Country:  Pakistan    
Other Details:
Languages:  eng     Pagination:  277-81     Citation Subset:  IM    
Affiliation:
Sindh Institute of Urology & Transplantation, Karachi, Pakistan. drmutarhirtonio@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Antimetabolites, Antineoplastic / adverse effects*
Bradycardia / chemically induced*
Deoxycytidine / adverse effects,  analogs & derivatives*
Fluorouracil / adverse effects,  analogs & derivatives*
Humans
Male
Middle Aged
Myocardial Ischemia / chemically induced*
Prodrugs / adverse effects*
Chemical
Reg. No./Substance:
0/Antimetabolites, Antineoplastic; 0/Prodrugs; 51-21-8/Fluorouracil; 6804DJ8Z9U/capecitabine; 951-77-9/Deoxycytidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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