| REPORT: Capecitabine induced cardiotoxicity: A case report and review of literature. | |
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MedLine Citation:
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PMID: 22186341 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Capecitabine is an oral prodrug of 5-fluorouracil (5-FU) which is converted in tumor cells to 5-FU by the enzyme thymidine phosphorylase. Nowadays, it is being widely used into the management of colorectal, breast and head and neck cancers because of its oral route and its comparable efficacy with 5-FU. 5-FU induced cardiotoxicity (angina and myocardial infarction) has been reported the literature, but capecitabine induced cardiotoxicity is less reported event. We report a patient with diagnosis of locally advanced adenocarcinoma of rectum who developed symptomatic bradycardia and acute ischemia while receiving oral capecitabine 825mg/m(2) twice daily with preoperative radiation. |
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Authors:
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Mutahar Ali Tunio; Altaf Hashmi; Muhammad Shoaib |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pakistan journal of pharmaceutical sciences Volume: 25 ISSN: 1011-601X ISO Abbreviation: Pak J Pharm Sci Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9426356 Medline TA: Pak J Pharm Sci Country: Pakistan |
Other Details:
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Languages: eng Pagination: 277-81 Citation Subset: IM |
Affiliation:
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Sindh Institute of Urology & Transplantation (SIUT), Karachi, Pakistan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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