Document Detail


REM sleep deprivation produces a motivational deficit for food reward that is reversed by intra-accumbens amphetamine in rats.
MedLine Citation:
PMID:  20619322     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prolonged sleep deprivation in rats produces a characteristic syndrome of increase in food intake accompanied by, paradoxically, decrease in weight, suggesting a potential alteration in motivation for food reward. Using the multiple platform method to produce REM sleep deprivation (REMSD), we investigated the effect of REMSD on motivation for food reinforcement with a progressive ratio operant task, which yields a measure of the motor effort that a hungry animal is willing to expend to obtain food (the point at which the animal quits responding is termed the "break-point"). We found that REMSD rats decreased the break point for sucrose pellet reinforcement in comparison to controls, as revealed by a within-session decline in responding. This behavioral deficit is similar to that observed in rats with diminished dopamine transmission within the nucleus accumbens (Acb), and, considering that stimulants are frequently used in the clinical setting to reverse the effects of sleepiness, we examined the effect of systemic or intra-Acb amphetamine on break point in REMSD rats. Animals were given either systemic or intra-Acb amphetamine injections on days 3 and 5 of REMSD. Systemic amphetamine (0.1, 0.5, or 2.5mg/kg) did not increase break point in REMSD rats. In contrast, intra-Acb infusions of amphetamine (1, 10, or 30μg/0.5μl bilaterally) reversed the REMSD-induced suppression of progressive ratio responding. Specifically, the two higher doses of intra-Acb amphetamine were able to prolong responding within the session (resulting in an increased break point) on day 3 of REMSD while only the highest dose was sufficient following 5 days of REMSD. These data suggest that decreased motivation for food reward caused by REMSD may result from a suppression of dopamine function in the Acb.
Authors:
Erin C Hanlon; Ruth M Benca; Brian A Baldo; Ann E Kelley
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-07-07
Journal Detail:
Title:  Brain research bulletin     Volume:  83     ISSN:  1873-2747     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-11     Completed Date:  2011-02-23     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Amphetamine / pharmacology*
Animals
Behavior, Animal / physiology
Central Nervous System Stimulants / pharmacology*
Conditioning, Operant
Dopamine / metabolism
Eating / drug effects
Food*
Male
Motivation* / drug effects,  physiology
Nucleus Accumbens / drug effects*
Rats
Rats, Sprague-Dawley
Reinforcement Schedule
Reward*
Sleep Deprivation / physiopathology*
Grant Support
ID/Acronym/Agency:
5 F31 MH070342-02/MH/NIMH NIH HHS; MH52226/MH/NIMH NIH HHS; R01 HL086465-01/HL/NHLBI NIH HHS; R01 HL086465-04/HL/NHLBI NIH HHS; R01 MH052226-09/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Central Nervous System Stimulants; CK833KGX7E/Amphetamine; VTD58H1Z2X/Dopamine
Comments/Corrections

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