Document Detail

An RCT on the effects of topical CGP on surgical wound appearance and residual scarring in bilateral total-knee arthroplasty patients.
MedLine Citation:
PMID:  22240886     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the hypothesis that topically applied calcium glycerophosphate (CGP) would improve the appearance of the wound following bilateral knee replacement.
METHOD: Healthy patients, aged 45-75 years, scheduled for bilateral total-knee replacement surgery were recruited into the study. One knee was randomly assigned to the treatment group, while the contralateral knee was designated the control (standard care). Subjects were instructed to apply a preparation of 10% CGP in an aqueous lotion to the treated knee once daily for 42 days, starting at the third postoperative day. Functional sealing and cosmetic appearance of the incision were evaluated by two surgeons by direct examination of the patient and then by two experienced assessors from photographs. The investigators qualitatively scored the intensity and extent of erythema along the incision and over the entire knee, the appearance of visible oedema along the incision and over the knee, and the overall clinical impression of wound healing. All four assessors were blinded to the subjects' allocation and the latter two assessors to the initial investigators' assessments. Subjects were also followed up for an additional 46 weeks, giving a total study duration of 12 months.
RESULTS: Twenty patients completed the study. Statistical analysis showed that both the area and intensity of erythema along the incision were significantly reduced in the treated vs untreated knee over the entire study period. The analysis further showed that treatment significantly reduced oedema, both along the incision and across the entire knee. The differences were most marked at the seventh postoperative day and diminished with time. No adverse effects were observed for any patient, in either treated or untreated knees.
CONCLUSION: These data demonstrate that postoperative application of 10% CGP could improve the appearance of the wound following total knee arthroplasty.
A Ong; F Orozco; E S Sheikh; C Anmuth; A Alfaro; R Kathrins; G L Grove; C Zerweck; A M Madden; R Raspa; M T Weis
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of wound care     Volume:  20     ISSN:  0969-0700     ISO Abbreviation:  J Wound Care     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-01-13     Completed Date:  2012-02-21     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  9417080     Medline TA:  J Wound Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  592-8     Citation Subset:  N    
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MeSH Terms
Administration, Topical
Arthroplasty, Replacement, Knee*
Cicatrix / prevention & control
Erythema / prevention & control
Glycerophosphates / administration & dosage*
Knee Joint / physiopathology
Middle Aged
Pain Measurement
Range of Motion, Articular
Wound Healing / drug effects*,  physiology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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