| RAS gene mutations in childhood acute myeloid leukemia: a Pediatric Oncology Group study. | |
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MedLine Citation:
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PMID: 2278970 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mutations at codon 12, 13, and 61 of the HRAS, KRAS, and NRAS genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, 13 in the KRAS gene, and none in the HRAS gene. The mutations occurred in a broad spectrum of cases, and there was no specific association of RAS gene mutations with patient subsets defined on the basis of clinical or hematologic features. These data demonstrate that RAS gene mutations are at least as common in childhood AML as in adult AML and suggest that RAS gene mutations play a role in myeloid neoplasia in both age groups. |
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Authors:
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B Vogelstein; C I Civin; A C Preisinger; J P Krischer; P Steuber; Y Ravindranath; H Weinstein; P Elfferich; J Bos |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Genes, chromosomes & cancer Volume: 2 ISSN: 1045-2257 ISO Abbreviation: Genes Chromosomes Cancer Publication Date: 1990 Jul |
Date Detail:
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Created Date: 1991-03-08 Completed Date: 1991-03-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9007329 Medline TA: Genes Chromosomes Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 159-62 Citation Subset: IM |
Affiliation:
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Johns Hopkins Oncology Center, Baltimore, Maryland 21231. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Alleles Child Child, Preschool Codon DNA Mutational Analysis DNA Probes DNA, Neoplasm / genetics Female Genes, ras* Humans Infant Leukemia, Myeloid, Acute / genetics* Male Mutation Polymerase Chain Reaction Proto-Oncogene Proteins p21(ras) / genetics |
| Grant Support | |
ID/Acronym/Agency:
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CA-03161/CA/NCI NIH HHS; CA-28476/CA/NCI NIH HHS; CA-29139/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Codon; 0/DNA Probes; 0/DNA, Neoplasm; EC 3.6.5.2/HRAS protein, human; EC 3.6.5.2/Proto-Oncogene Proteins p21(ras) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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