Document Detail


RAS gene mutations in childhood acute myeloid leukemia: a Pediatric Oncology Group study.
MedLine Citation:
PMID:  2278970     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mutations at codon 12, 13, and 61 of the HRAS, KRAS, and NRAS genes were evaluated in 99 cases of pediatric acute myeloid leukemia (AML) using oligonucleotide hybridization to polymerase chain reacted derived products. Twenty-four mutations were identified in the NRAS gene, 13 in the KRAS gene, and none in the HRAS gene. The mutations occurred in a broad spectrum of cases, and there was no specific association of RAS gene mutations with patient subsets defined on the basis of clinical or hematologic features. These data demonstrate that RAS gene mutations are at least as common in childhood AML as in adult AML and suggest that RAS gene mutations play a role in myeloid neoplasia in both age groups.
Authors:
B Vogelstein; C I Civin; A C Preisinger; J P Krischer; P Steuber; Y Ravindranath; H Weinstein; P Elfferich; J Bos
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Genes, chromosomes & cancer     Volume:  2     ISSN:  1045-2257     ISO Abbreviation:  Genes Chromosomes Cancer     Publication Date:  1990 Jul 
Date Detail:
Created Date:  1991-03-08     Completed Date:  1991-03-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9007329     Medline TA:  Genes Chromosomes Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Affiliation:
Johns Hopkins Oncology Center, Baltimore, Maryland 21231.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Alleles
Child
Child, Preschool
Codon
DNA Mutational Analysis
DNA Probes
DNA, Neoplasm / genetics
Female
Genes, ras*
Humans
Infant
Leukemia, Myeloid, Acute / genetics*
Male
Mutation
Polymerase Chain Reaction
Proto-Oncogene Proteins p21(ras) / genetics
Grant Support
ID/Acronym/Agency:
CA-03161/CA/NCI NIH HHS; CA-28476/CA/NCI NIH HHS; CA-29139/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Codon; 0/DNA Probes; 0/DNA, Neoplasm; EC 3.6.5.2/HRAS protein, human; EC 3.6.5.2/Proto-Oncogene Proteins p21(ras)

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