| RANTES: a new prostaglandin dependent endogenous pyrogen in the rat. | |
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MedLine Citation:
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PMID: 10974335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fever, a hallmark of disease, is a highly complex process initiated by the action of a number of endogenous pyrogens on the thermosensitive cells of the brain. We describe the activity of RANTES, a chemotactic cytokine, as intrinsically pyrogenic in the rat, when it is delivered directly to the thermosensitive region of the rat's anterior hypothalamic, pre-optic area (AH/POA). RANTES, microinjected into the AH/POA in a dose of 1, 5, 10, 15, 25 or 50 pg, produces an immediate and intense dose-related fever following injection. Increasing the dose to 100 pg did not result in a further increase in the febrile response. No significant change in body temperature was produced by heat-inactivated RANTES. The intrahypothalamic injection of antibodies against RANTES (2.0 microg, 15 min prior to RANTES) significantly blocked the fever induced by this chemokine. Pretreatment with ibuprofen blocked the fever induced by RANTES. In order of potency, the magnitude of the febrile response induced by RANTES was greater than that produced with equipotent doses of either macrophage inflammatory protein-1beta or interleukin-6. The results thus demonstrate that RANTES is the most potent endopyrogen discovered thus far and exerts its action directly on pyrogen-sensitive cells of the AH/POA through a prostaglandin-dependent pathway. |
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Authors:
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E Tavares; F J Miñano |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuropharmacology Volume: 39 ISSN: 0028-3908 ISO Abbreviation: Neuropharmacology Publication Date: 2000 Sep |
Date Detail:
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Created Date: 2000-11-13 Completed Date: 2000-11-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 2505-13 Citation Subset: IM |
Affiliation:
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Neuropharmacology Research Group, Department of Pharmacology, School of Medicine, University of Seville, Seville, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Temperature Regulation / drug effects Chemokine CCL5 / administration & dosage, pharmacology* Cyclooxygenase Inhibitors / pharmacology Hypothalamus, Anterior / anatomy & histology, physiology Ibuprofen / pharmacology Interleukin-6 / pharmacology Male Microinjections Preoptic Area / anatomy & histology, physiology Prostaglandins / physiology* Pyrogens / administration & dosage, pharmacology* Rats Rats, Wistar Recombinant Proteins / administration & dosage, pharmacology Transcription Factors / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Chemokine CCL5; 0/Cyclooxygenase Inhibitors; 0/Interleukin-6; 0/MNP-1 protein, human; 0/Prostaglandins; 0/Pyrogens; 0/Recombinant Proteins; 0/Transcription Factors; 15687-27-1/Ibuprofen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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