Document Detail


RAMP: A Bioinformatics Framework for Researching Imaging Agents through Molecular Pathways.
MedLine Citation:
PMID:  23348786     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
AbstractSignaling pathways are the fundamental grammar of cellular communication, yet few frameworks are available to analyze molecular imaging probes in the context of signaling pathways. Such a framework would aid in the design and selection of imaging probes for measuring specific signaling pathways and, vice versa, help illuminate which pathways are being assayed by a given probe. RAMP (Researching imaging Agents through Molecular Pathways) is a bioinformatics framework for connecting signaling pathways and imaging probes using a controlled vocabulary of the imaging targets. RAMP contains signaling pathway data from MetaCore, the Kyoto Encyclopedia of Genes and Genomes, and the Gene Ontology project; imaging probe data from the Molecular Imaging and Contrast Agent Database (MICAD); and tissue protein expression data from The Human Protein Atlas. The RAMP search tool is available at <http://www.rampsearch.com>. Examples are presented to demonstrate the utility of RAMP for pathway-based searches of molecular imaging probes.
Authors:
Edward Khokhlovich; Daniel Wahl; Anthony Masiello; Pierre Parisot; Stefan El-Ghatta; Joseph D Szustakowski; Nanguneri Nirmala; David S Tuch
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular imaging     Volume:  12     ISSN:  1536-0121     ISO Abbreviation:  Mol Imaging     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101120118     Medline TA:  Mol Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2-7     Citation Subset:  IM    
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