Document Detail

R(1) and R(2) * changes in the human placenta in response to maternal oxygen challenge.
MedLine Citation:
PMID:  23280967     Owner:  NLM     Status:  Publisher    
PURPOSE: Pregnancy complications such as preeclampsia and fetal growth restriction are sometimes thought to be caused by placental abnormalities associated with reduced oxygenation. Oxygen-enhanced MRI (R(1) contrast) and BOLD MRI (R(2) * contrast) have the potential to noninvasively investigate this oxygen environment at a range of gestational ages. METHODS: Scanning was carried out at 1.5 T under maternal air and oxygen breathing in a single placental slice in 14 healthy pregnant subjects of gestational ages 21-37 weeks. We report R(1) changes using a respiratory-triggered inversion recovery-turbo spin-echo sequence, which is sensitive to changes in PO(2) , and R(2) * changes using a breathhold multiple gradient-recalled echo sequence sensitive to changes in oxygen saturation. RESULTS: Significant R(1) increases (P < 0.005, paired t-test) and R(2) * decreases (P < 0.0001, paired t-test) between air and oxygen breathing were demonstrated. ΔR(1) decreased with gestational age (P < 0.0005, r = -0.835, Pearson correlation test). No significant effect of gestational age on R(2) * change was observed. CONCLUSION: The results demonstrate the feasibility of non-invasive investigation of placental oxygenation using MRI and the sensitivity of R(1) oxygen-enhanced MRI to gestational age. The techniques have the potential to provide unique noninvasive biomarkers in compromised pregnancies. Magn Reson Med, 2012. © 2012 Wiley Periodicals, Inc.
Isaac Huen; David M Morris; Caroline Wright; Geoff J M Parker; Colin P Sibley; Edward D Johnstone; Josephine H Naish
Related Documents :
17855687 - Plasma volume expansion in pregnancy: implications for biomarkers in population studies.
7924007 - Glomerular filtration and volume regulation in gravid animal models.
20846067 - Pharmacokinetics of chemotherapeutic agents in pregnancy: a preclinical and clinical st...
9127127 - Fetal plasma lipid peroxide levels in pregnancies complicated by preeclampsia.
984147 - Nonstressed fetal heart rate monitoring in the antepartum period.
2209897 - Successful pregnancies resulting from the use of prolonged-incubation human spermatozoa...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-27
Journal Detail:
Title:  Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine     Volume:  -     ISSN:  1522-2594     ISO Abbreviation:  Magn Reson Med     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-1-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8505245     Medline TA:  Magn Reson Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Centre for Imaging Sciences, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK; The University of Manchester Biomedical Imaging Institute, University of Manchester, Manchester, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intra-arterial cisplatin with concomitant radiation for advanced hypopharyngeal cancer.
Next Document:  Bayesian analysis of recurrent event with dependent termination: an application to a heart transplan...