Document Detail

R-wave voltage in the right precordial leads in anthracycline cardiomyopathy: a clinical study.
MedLine Citation:
PMID:  3253219     Owner:  NLM     Status:  MEDLINE    
It was observed that the QS pattern in the right precordial leads of electrocardiograms of patients treated with anthracycline antibiotics resulted in congestive heart failure. In a review of the literature dealing with patients with anthracycline cardiomyopathy, terminal electrocardiograms, when available, showed the QS pattern in the right precordial leads in all patients. The relationship between a decreased R-wave voltage in lead V1 and an increase of the anthracycline dose was evaluated by a clinical study of ten patients. Analysis was subdivided into two categories (group A and B). In group A, there was a dose-response relationship. Electrocardiograms in group B, on the other hand, did not show low R-waves. The present study suggests that increased injury to myocardial cells in the regions of the anterior septum and anterior left ventricular wall might be important in the pathogenesis of anthracycline cardiomyopathy. Patients in group B seemed to be able to tolerate chronic anthracycline cardiac toxicity.
Z Onouchi; H Tamiya; Y Sakakibara; M Ando; T Fujimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of clinical pharmacology research     Volume:  8     ISSN:  0251-1649     ISO Abbreviation:  Int J Clin Pharmacol Res     Publication Date:  1988  
Date Detail:
Created Date:  1989-08-18     Completed Date:  1989-08-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8110183     Medline TA:  Int J Clin Pharmacol Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  423-31     Citation Subset:  IM    
Department of Paediatrics, Aichi Medical University, Japan.
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MeSH Terms
Antibiotics, Antineoplastic / toxicity*
Cardiomyopathies / chemically induced*,  physiopathology
Child, Preschool
Dose-Response Relationship, Drug
Heart Failure / chemically induced*,  physiopathology
Middle Aged
Monitoring, Physiologic
Neoplasms / drug therapy
Reg. No./Substance:
0/Antibiotics, Antineoplastic

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