| R-wave voltage in the right precordial leads in anthracycline cardiomyopathy: a clinical study. | |
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MedLine Citation:
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PMID: 3253219 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It was observed that the QS pattern in the right precordial leads of electrocardiograms of patients treated with anthracycline antibiotics resulted in congestive heart failure. In a review of the literature dealing with patients with anthracycline cardiomyopathy, terminal electrocardiograms, when available, showed the QS pattern in the right precordial leads in all patients. The relationship between a decreased R-wave voltage in lead V1 and an increase of the anthracycline dose was evaluated by a clinical study of ten patients. Analysis was subdivided into two categories (group A and B). In group A, there was a dose-response relationship. Electrocardiograms in group B, on the other hand, did not show low R-waves. The present study suggests that increased injury to myocardial cells in the regions of the anterior septum and anterior left ventricular wall might be important in the pathogenesis of anthracycline cardiomyopathy. Patients in group B seemed to be able to tolerate chronic anthracycline cardiac toxicity. |
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Authors:
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Z Onouchi; H Tamiya; Y Sakakibara; M Ando; T Fujimoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of clinical pharmacology research Volume: 8 ISSN: 0251-1649 ISO Abbreviation: Int J Clin Pharmacol Res Publication Date: 1988 |
Date Detail:
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Created Date: 1989-08-18 Completed Date: 1989-08-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110183 Medline TA: Int J Clin Pharmacol Res Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 423-31 Citation Subset: IM |
Affiliation:
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Department of Paediatrics, Aichi Medical University, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Antibiotics, Antineoplastic / toxicity* Cardiomyopathies / chemically induced*, physiopathology Child Child, Preschool Dose-Response Relationship, Drug Electrocardiography* Female Heart Failure / chemically induced*, physiopathology Humans Male Middle Aged Monitoring, Physiologic Neoplasms / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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