Document Detail

R-plasmid transfer in vivo in the absence of antibiotic selection pressure.
MedLine Citation:
PMID:  791109     Owner:  NLM     Status:  MEDLINE    
The persistence of an O18 Escherichia coli strain resistant to tetracycline, streptomycin, and sulfonamide has been followed in the fecal flora of a single individual over a period of 9 months. The strain in question carrying an R plasmid was detectable from the beginning of the survey, but it was only after a 10-day period of tetracycline therapy that it reached an all but permanent dominance in the fecal flora. No transfer of the R plasmid carried by the strain to any other coliform could be detected for 202 days after the end of tetracycline treatment. At this point, however, an O88 E. coli carrying the same plasmid as the O18 strain appeared briefly as a predominant component of the flora. The two plasmids isolated from the O18 and the O88 E. coli strains have been characterized in molecular terms and found to be similar. This suggests that R-plasmid transfer between two E. coli strains occurred in an individual who was living a normal daily life and who was not receiving antibiotics.
V Petrocheilou; J Grinsted; M H Richmond
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  10     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-30     Completed Date:  1976-12-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  753-61     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / pharmacology*
Conjugation, Genetic
Culture Media
DNA, Bacterial / isolation & purification
Drug Resistance, Microbial*
Escherichia coli / drug effects*
R Factors*
Transduction, Genetic
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Culture Media; 0/DNA, Bacterial; EC 3.1.-/Endonucleases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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