Document Detail


R-PEP-27, a potent renin inhibitor, decreases plasma angiotensin II and blood pressure in normal volunteers.
MedLine Citation:
PMID:  8031544     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hemodynamic and humoral effects of the specific human renin inhibitor R-PEP-27 were studied in six normal human subjects on low and high sodium intake diets. An intravenous infusion of R-PEP-27 (0.5 to 16 micrograms/min/kg body wt) reduced blood pressure in a dose-dependent fashion; the mean arterial blood pressure at the end of the infusion fell from 128 +/- 4/83 +/- 4 to 119 +/- 3/71 +/- 3 mm Hg (mean +/- SEM) (P < .01) during the low sodium intake diet. R-PEP-27 had no effect on blood pressure during the high sodium intake diet. R-PEP-27 significantly reduced plasma angiotensin II and aldosterone concentrations. The temporal response to R-PEP-27 suggests that it is a short-lived although highly potent competitive inhibitor of renin; this peptide is a valuable and specific physiologic probe of the renin-angiotensin system.
Authors:
R M Zusman; K Y Hui; J Nussberger; D M Christensen; J Higgins; W D Carlson; D Schoenfeld; E Haber
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hypertension     Volume:  7     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-12     Completed Date:  1994-08-12     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  295-301     Citation Subset:  IM    
Affiliation:
Division of Hypertension and Vascular Medicine, Massachusetts General Hospital, Boston 02114.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aldosterone / blood
Angiotensin II / blood*
Blood Pressure / drug effects*
Female
Homeostasis
Humans
Male
Middle Aged
Oligopeptides / adverse effects,  pharmacology*
Osmolar Concentration
Reference Values
Renin / antagonists & inhibitors*
Urine / chemistry
Grant Support
ID/Acronym/Agency:
RR0166-12/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Oligopeptides; 103122-78-7/renin inhibitory peptide, R-PEP-27; 11128-99-7/Angiotensin II; 52-39-1/Aldosterone; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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