Document Detail


Quorum-sensing signal synthesis by the Yersinia pestis acyl-homoserine lactone synthase YspI.
MedLine Citation:
PMID:  16385067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The acyl-homoserine lactone molecular species (AHLs) produced by the Yersinia pestis AHL synthase YspI were identified by biochemical and physical/chemical techniques. Bioassays of extracts from culture supernatants of the recombinant YspI and wild-type Yersinia pestis showed similar profiles of AHLs. Analysis by liquid chromatography-mass spectrometry revealed that the predominant AHLs were N-3-oxooctanoyl-L-homoserine lactone and N-3-oxo-hexanoyl-L-homoserine lactone.
Authors:
J Paul Kirwan; Ty A Gould; Herbert P Schweizer; Scott W Bearden; Robert C Murphy; Mair E A Churchill
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of bacteriology     Volume:  188     ISSN:  0021-9193     ISO Abbreviation:  J. Bacteriol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-30     Completed Date:  2006-02-23     Revised Date:  2014-09-10    
Medline Journal Info:
Nlm Unique ID:  2985120R     Medline TA:  J Bacteriol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  784-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
4-Butyrolactone / analogs & derivatives,  analysis,  metabolism
Amino Acid Sequence
Escherichia coli / metabolism
Gas Chromatography-Mass Spectrometry
Ligases / genetics,  metabolism*
Molecular Sequence Data
Operon / genetics
Recombinant Proteins / metabolism
Yersinia pestis / enzymology,  physiology*
Grant Support
ID/Acronym/Agency:
AI48660/AI/NIAID NIH HHS; GM69338/GM/NIGMS NIH HHS; R01 AI048660/AI/NIAID NIH HHS; R01 AI048660-01A1/AI/NIAID NIH HHS; R01 AI048660-02/AI/NIAID NIH HHS; R01 AI048660-03/AI/NIAID NIH HHS; R01 AI048660-04/AI/NIAID NIH HHS; R01 AI048660-05/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 1192-20-7/homoserine lactone; 76924-95-3/N-(3-oxohexanoyl)-3-aminodihydro-2(3H)-furanone; EC 6.-/Ligases; EC 6.1.-/N-acylhomoserine lactone synthase; OL659KIY4X/4-Butyrolactone
Comments/Corrections

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