Document Detail


Quinone formation from benzo[a]pyrene by free radicals: effects of antioxidants.
MedLine Citation:
PMID:  3360379     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Liposomes comprising dimyristoylphosphatidylcholine and benzo[a]pyrene (B[a]P) were incubated at 37 degrees C in the presence of a water-soluble azo initiator. B[a]P 1,6-, 3,6- and 6,12-quinone were formed with the generation of peroxyl radicals by the thermal decomposition of the initiator in an aqueous phase of the suspension. Vitamin E showed little inhibitory effect on B[a]P quinone formation. Uric acid was found to suppress B[a]P quinone formation completely at a concentration lower than that of vitamin C, indicating that uric acid in an aqueous phase traps peroxyl radicals more effectively.
Authors:
J Terao; S Matsushita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Free radical biology & medicine     Volume:  4     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  1988  
Date Detail:
Created Date:  1988-06-03     Completed Date:  1988-06-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-8     Citation Subset:  IM    
Affiliation:
Research Institute for Food Science, Kyoto University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Amidines / diagnostic use
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology
Benzo(a)pyrene*
Free Radicals
Quinones*
Uric Acid / pharmacology
Vitamin E / pharmacology
Chemical
Reg. No./Substance:
0/Amidines; 0/Antioxidants; 0/Free Radicals; 0/Quinones; 13217-66-8/2,2'-azobis(2-amidinopropane); 1406-18-4/Vitamin E; 50-32-8/Benzo(a)pyrene; 50-81-7/Ascorbic Acid; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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