Document Detail

Quinolone resistance mechanisms in pneumococci.
MedLine Citation:
PMID:  15127369     Owner:  NLM     Status:  MEDLINE    
Quinolones are widely used in the treatment of respiratory infections, in large part because of their activity against Streptococcus pneumoniae and other commonly encountered respiratory tract pathogens. Pneumococcal isolates that are resistant to these "respiratory quinolones" have now begun to emerge. Resistance is attributable to mutations affecting the intracellular targets of these drugs, topoisomerase IV and DNA gyrase; drug efflux contributes to quinolone resistance in some isolates. Most commonly, strains fully resistant to the newer quinolones have one or more mutations affecting DNA gyrase and topoisomerase IV. Although various agents of this class exhibit selectivity in primarily targeting one or the other of these enzymes, the passage of isolates in the presence of any agent can result in selection of mutations affecting both enzymes. Quinolone resistance in S. pneumoniae has arisen in heterogeneous genetic backgrounds but, ominously, has now appeared in strains that are well adapted for regional and global transmission.
George M Eliopoulos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  38 Suppl 4     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-05     Completed Date:  2004-06-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S350-6     Citation Subset:  IM    
Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA.
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MeSH Terms
Anti-Infective Agents
DNA Gyrase / genetics*,  physiology
DNA Topoisomerase IV / genetics*,  physiology
Drug Resistance, Bacterial / genetics*
Microbial Sensitivity Tests
Quinolones / pharmacology*
Streptococcus pneumoniae / drug effects*,  isolation & purification
Reg. No./Substance:
0/Anti-Infective Agents; 0/Quinolones; EC 5.99.1.-/DNA Gyrase; EC 5.99.1.-/DNA Topoisomerase IV

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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