| Quinolinic acid evokes [3H]acetylcholine release in striatal slices: mediation by NMDA-type excitatory amino acid receptors. | |
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MedLine Citation:
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PMID: 6141057 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quinolinic acid evoked the release of [3H]acetylcholine from striatal slices with an EC50 of approximately 2 mM and an efficacy similar to that of N-methyl-D,L-aspartic acid. (+/-)-2-Amino-5-phosphonopentanoic acid and (-)-2-amino-7-phosphonoheptanoic acid antagonized quinolinic acid-evoked release, while glutamate diethylester and 2-amino-4-phosphonobutyric acid were ineffective as antagonists. Release of [3H]acetylcholine evoked by quinolinic acid was strongly attenuated by the presence of magnesium (1.2 mM) in the medium. The results are consistent with the interaction of quinolinic acid with NMDA-type excitatory amino acid receptors on the striatal cholinergic interneurons. |
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Authors:
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J Lehmann; P Schaefer; J W Ferkany; J T Coyle |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 96 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1983 Dec |
Date Detail:
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Created Date: 1984-03-02 Completed Date: 1984-03-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 111-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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2-Amino-5-phosphonovalerate Acetylcholine / metabolism* Amino Acids / pharmacology Aminobutyric Acids / pharmacology Animals Corpus Striatum / drug effects* Drug Interactions Male Pyridines / pharmacology* Quinolinic Acid Quinolinic Acids / antagonists & inhibitors, pharmacology* Rats Rats, Inbred Strains Receptors, Cell Surface / drug effects* Receptors, N-Methyl-D-Aspartate Tritium Valine / analogs & derivatives, pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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MH00125/MH/NIMH NIH HHS; NS13584/NS/NINDS NIH HHS; NS18414/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Aminobutyric Acids; 0/Pyridines; 0/Quinolinic Acids; 0/Receptors, Cell Surface; 0/Receptors, N-Methyl-D-Aspartate; 10028-17-8/Tritium; 51-84-3/Acetylcholine; 6323-99-5/2-amino-4-phosphonobutyric acid; 7004-03-7/Valine; 76726-92-6/2-Amino-5-phosphonovalerate; 85797-13-3/2-amino-7-phosphonoheptanoic acid; 89-00-9/Quinolinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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