Document Detail


Quinolinic acid evokes [3H]acetylcholine release in striatal slices: mediation by NMDA-type excitatory amino acid receptors.
MedLine Citation:
PMID:  6141057     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quinolinic acid evoked the release of [3H]acetylcholine from striatal slices with an EC50 of approximately 2 mM and an efficacy similar to that of N-methyl-D,L-aspartic acid. (+/-)-2-Amino-5-phosphonopentanoic acid and (-)-2-amino-7-phosphonoheptanoic acid antagonized quinolinic acid-evoked release, while glutamate diethylester and 2-amino-4-phosphonobutyric acid were ineffective as antagonists. Release of [3H]acetylcholine evoked by quinolinic acid was strongly attenuated by the presence of magnesium (1.2 mM) in the medium. The results are consistent with the interaction of quinolinic acid with NMDA-type excitatory amino acid receptors on the striatal cholinergic interneurons.
Authors:
J Lehmann; P Schaefer; J W Ferkany; J T Coyle
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of pharmacology     Volume:  96     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-03-02     Completed Date:  1984-03-02     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  111-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
2-Amino-5-phosphonovalerate
Acetylcholine / metabolism*
Amino Acids / pharmacology
Aminobutyric Acids / pharmacology
Animals
Corpus Striatum / drug effects*
Drug Interactions
Male
Pyridines / pharmacology*
Quinolinic Acid
Quinolinic Acids / antagonists & inhibitors,  pharmacology*
Rats
Rats, Inbred Strains
Receptors, Cell Surface / drug effects*
Receptors, N-Methyl-D-Aspartate
Tritium
Valine / analogs & derivatives,  pharmacology
Grant Support
ID/Acronym/Agency:
MH00125/MH/NIMH NIH HHS; NS13584/NS/NINDS NIH HHS; NS18414/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Aminobutyric Acids; 0/Pyridines; 0/Quinolinic Acids; 0/Receptors, Cell Surface; 0/Receptors, N-Methyl-D-Aspartate; 10028-17-8/Tritium; 51-84-3/Acetylcholine; 6323-99-5/2-amino-4-phosphonobutyric acid; 7004-03-7/Valine; 76726-92-6/2-Amino-5-phosphonovalerate; 85797-13-3/2-amino-7-phosphonoheptanoic acid; 89-00-9/Quinolinic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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