| Quinolinic acid concentrations in brain and cerebrospinal fluid of patients with intractable complex partial seizures. | |
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MedLine Citation:
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PMID: 1690639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quinolinic acid (QUIN) is a neurotoxin and convulsant when injected directly into the brains of experimental animals and as such has been implicated in the etiology of human seizure disorders. In the present study, we quantified QUIN in cerebrospinal fluid (CSF) and in spiking (focus) and nonspiking (nonfocus) regions of surgically resected human temporal neocortex. L-tryptophan (L-TRP), the putative precursor of QUIN, was also measured in brain, along with CSF concentrations of L-TRP, 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA). In brain tissue, no differences were found in the concentrations of QUIN and L-TRP between focus and nonfocus regions in 15 pairs of samples. No differences were found in CSF, L-TRP, 5-HIAA, or HVA concentrations between 11 neurologically normal controls and 15 interictal (no seizures for greater than 24 h) and 20 postictal (within 50 min of seizure) samples from epileptic patients. However, CSF QUIN concentrations were significantly lower (32%) in the epileptic patients as compared with controls, which may indicate a generalized disturbance in brain QUIN metabolism or perhaps a response to antiepileptic drugs. |
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Authors:
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M P Heyes; A R Wyler; O Devinsky; J A Yergey; S P Markey; N S Nadi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Epilepsia Volume: 31 ISSN: 0013-9580 ISO Abbreviation: Epilepsia Publication Date: 1990 Mar-Apr |
Date Detail:
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Created Date: 1990-05-01 Completed Date: 1990-05-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 2983306R Medline TA: Epilepsia Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 172-7 Citation Subset: IM |
Affiliation:
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Section on Analytical Biochemistry, NIMH, Bethesda, Maryland 20892. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Brain Chemistry* Child Epilepsy, Temporal Lobe / cerebrospinal fluid, metabolism* Homovanillic Acid / analysis, cerebrospinal fluid Humans Hydroxyindoleacetic Acid / analysis, cerebrospinal fluid Middle Aged Pyridines / analysis* Quinolinic Acid Quinolinic Acids / analysis*, cerebrospinal fluid Tryptophan / analysis, cerebrospinal fluid |
| Chemical | |
Reg. No./Substance:
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0/Pyridines; 0/Quinolinic Acids; 306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; 73-22-3/Tryptophan; 89-00-9/Quinolinic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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