| Quinine-induced hypothermia in cold-exposed rats. | |
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MedLine Citation:
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PMID: 896891 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Quinine HCl in doses from 10-50 mg/kg lowered the body temperatures of nonfebrile rats in the cold, primarily by suppressing shivering. However, if given an opportunity to turn on a heat lamp the rats worked much more than normal after a quinine injection and were theraby able to counteract the hypothermia to some extent. The effect of quinine is interpreted as an action on effector mechanisms rather than as an alteration of the thermal setpoint. |
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Authors:
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E Satinoff |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 6 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1977 May |
Date Detail:
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Created Date: 1977-10-14 Completed Date: 1977-10-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 539-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / drug effects Body Temperature / drug effects Body Temperature Regulation / drug effects Cold Temperature Conditioning, Operant / drug effects Depression, Chemical Female Food Heart Rate / drug effects Hot Temperature Hypothermia / chemically induced*, physiopathology Oxygen Consumption / drug effects Quinine / pharmacology* Rats Reinforcement (Psychology) Shivering / drug effects Time Factors Work |
| Chemical | |
Reg. No./Substance:
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130-95-0/Quinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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