| Quinine-induced hepatotoxicity. | |
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MedLine Citation:
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PMID: 9972382 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To report a case of quinine-induced hepatotoxicity presenting within 24 hours following the ingestion of the first dose. DATA SOURCES: Case report information was obtained from the medical record, the patient, and the physicians involved in this patient's case. MEDLINE and Index Medicus were searched to obtain relevant published literature from January 1942 to May 1997 using the terms quinine, muscle cramps, liver disease, and hepatotoxicity. CASE SUMMARY: A 57-year-old Native American woman presented with symptoms of nausea, vomiting, generalized myalgia, headache, fever, chills, and rigor. The alkaline phosphatase, lactate dehydrogenase, aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltranspeptidase concentrations were dramatically elevated. Quinine was suspected as the cause after several days of hospitalization and continued therapy. With discontinuation of the quinine, the patient's symptoms resolved within 48 hours and the liver enzyme concentrations declined within 72 hours. CONCLUSIONS: Documented hepatotoxicity has occurred with quinidine, the optical isomer of quinine. Limited awareness of quinine-induced hepatotoxicity may result in an unrecognized adverse effect. |
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Authors:
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D K Farver; M N Lavin |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Annals of pharmacotherapy Volume: 33 ISSN: 1060-0280 ISO Abbreviation: Ann Pharmacother Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-03-29 Completed Date: 1999-03-29 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 9203131 Medline TA: Ann Pharmacother Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 32-4 Citation Subset: IM |
Affiliation:
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College of Pharmacy, South Dakota State University, Sacred Heart Hospital, Yankton 57078, USA. dfarver@sunflowr.usd.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Drug-Induced Liver Injury* Female Humans Leg / physiopathology MEDLINE Middle Aged Muscle Cramp / drug therapy, physiopathology Muscle Relaxants, Central / adverse effects*, therapeutic use Muscle, Skeletal / physiopathology Quinine / adverse effects*, therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Muscle Relaxants, Central; 130-95-0/Quinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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