Document Detail

Quinine-induced hemolytic-uremic syndrome.
MedLine Citation:
PMID:  10923967     Owner:  NLM     Status:  MEDLINE    
Quinine is still frequently used by practitioners for the treatment of nocturnal leg cramps, despite the lack of Food and Drug Administration (FDA) approval. We report the 15th case of quinine-induced hemolytic-uremic syndrome (HUS) in the medical literature. The likely mechanism by which quinine induces HUS is via quinine-dependent antibodies to blood cellular constituents. These antibodies likely cause endothelial damage and the resultant nephropathy, microangiopathic hemolytic anemia, and thrombocytopenia that define HUS. Although there is no set guideline for the treatment of quinine-induced HUS, most authorities consider plasmapheresis as the standard of care, especially in severe cases. Our patient required the longest known treatment duration (16 plasmapheresis treatments over a 37-day period) for disease resolution. The prognosis of quinine-induced HUS is excellent, with no deaths reported in the literature.
N F Crum; P Gable
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Southern medical journal     Volume:  93     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-18     Completed Date:  2000-08-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  726-8     Citation Subset:  AIM; IM    
Department of Internal Medicine, Naval Medical Center, San Diego, Calif 92134-5000, USA.
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MeSH Terms
Hemolytic-Uremic Syndrome / chemically induced*,  physiopathology
Muscle Cramp / drug therapy
Muscle Relaxants, Central / adverse effects*
Quinine / adverse effects*
Renal Dialysis
Time Factors
Reg. No./Substance:
0/Muscle Relaxants, Central; 130-95-0/Quinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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