Document Detail


Quinidine-induced ventricular flutter and fibrillation without digitalis therapy.
MedLine Citation:
PMID:  970334     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Three cases are described with documented ventricular flutter and fibrillation during quinidine medication without concomitant digitalis therapy. In all three patients the arrhythmia developed while they were receiving moderate doses of quinidine. Although no changes in QRS width were observed after administration of quinidine, there was marked prolongation of the Q-T interval. The mechanism of development of ventricular flutter and fibrillation in patients taking quinidine may be similar to that in patients with the Q-T prolongation syndrome.
Authors:
R W Koster; H J Wellens
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  38     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-01     Completed Date:  1976-12-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  519-23     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Arrhythmias, Cardiac / chemically induced*,  physiopathology
Dose-Response Relationship, Drug
Female
Heart Ventricles / drug effects*,  physiopathology
Humans
Middle Aged
Quinidine / adverse effects*,  therapeutic use
Tachycardia, Paroxysmal / drug therapy
Ventricular Fibrillation / chemically induced*,  physiopathology
Chemical
Reg. No./Substance:
56-54-2/Quinidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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