| Quinidine hepatotoxicity. A report of a case and review of the literature. | |
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MedLine Citation:
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PMID: 1269875 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A case is described of presumed quinidine hepatotoxicity, characterized by the development of fever, abnormal serum transaminase values, which improved after cessation of the drug but recurred after a challenge dose, and centrizonal hepatocellular necrosis detected on liver biopsy. Morphological changes on electron microscopy, consistent with a drug reaction, are also described. Pertinent features of previous case reports are analyzed, and the histological findings by light microscopy of the present and past cases are discussed. It is suggested that the development of unexplained fever within 1 month of quinidine administration should lead to consideration of possible hepatotoxicity. |
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Authors:
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M J Koch; L B Seeff; C E Crumley; L Rabin; W A Burns |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Gastroenterology Volume: 70 ISSN: 0016-5085 ISO Abbreviation: Gastroenterology Publication Date: 1976 Jun |
Date Detail:
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Created Date: 1976-08-02 Completed Date: 1976-08-02 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0374630 Medline TA: Gastroenterology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1136-40 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Aspartate Aminotransferases / blood Drug-Induced Liver Injury / etiology*, pathology Humans Liver / drug effects* Male Middle Aged Quinidine / adverse effects* |
| Chemical | |
Reg. No./Substance:
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56-54-2/Quinidine; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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