Document Detail

Quinaprilat-eluting stents do not attenuate intimal thickening following stenting in porcine coronary arteries.
MedLine Citation:
PMID:  19135197     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Vascular injury increases angiotensin-converting enzyme (ACE) activity in the vessel wall, and experimental evidence suggests that high-dose oral ACE inhibition reduces intimal hyperplasia following balloon angioplasty. Local drug delivery can achieve high local concentrations which may be especially efficacious in inhibiting tissue growth following stent implantation. The aim of this study was to evaluate the angiographic and histomorphologic effects of quinaprilat-eluting stents in normal porcine coronary arteries.
METHODS: Ten pigs received phosphorylcholine-coated stents in each of the three major coronary arteries: one loaded with 780 microg quinaprilat, one with the solvent and one non-loaded control. Quantitative angiography was performed before and after stenting and at 4 weeks follow-up. At this time point the stented arteries were also analyzed using histology and morphometry.
RESULTS: Repeated measures ANOVA yielded significantly smaller angiographic lumen in both quinaprilat and solvent groups: 2.62+/-0.31 and 2.65+/-0.31 mm, respectively versus control: 2.70+/-0.32 mm at follow-up, p<0.05. Histology confirmed this finding with an increment in intimal area (2.5+/-0.86 mm(2)) and thickness (0.57+/-0.29 mm) in the quinaprilat group; versus solvent (1.98+/-0.57 mm(2) 0.4+/-0.26 mm) and controls (1.92+/-0.50mm(2) and 0.41+/-0.18 mm).
CONCLUSION: Quinaprilat-eluting stents do not attenuate neointimal thickening following implantation in normal porcine coronary arteries, but rather show a tendency towards the opposite.
Heleen M M van Beusekom; Valeria Ferrero; Flavio Ribichini; Willem J van der Giessen
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Publication Detail:
Type:  Journal Article     Date:  2008-12-06
Journal Detail:
Title:  Atherosclerosis     Volume:  205     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-08-25     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  120-5     Citation Subset:  IM    
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MeSH Terms
Angiography / methods
Angioplasty, Balloon / adverse effects
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Blood Vessel Prosthesis Implantation / adverse effects
Coronary Vessels / pathology*
Drug-Eluting Stents*
Hyperplasia / pathology
Peptidyl-Dipeptidase A / metabolism
Phosphorylcholine / chemistry
Tetrahydroisoquinolines / pharmacology*
Tunica Intima / pathology*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Tetrahydroisoquinolines; 107-73-3/Phosphorylcholine; 34SSX5LDE5/quinaprilat; EC A

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