| Quinapril and its metabolite quinaprilat in human milk. | |
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MedLine Citation:
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PMID: 11422007 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: To measure the milk to plasma ratio (M/P) of quinapril and its active metabolite quinaprilat in lactating mothers and to assess likely infant exposure. METHODS: A single dose of quinapril 20 mg was administered to six healthy mothers who had been breastfeeding their infants for at least 2 weeks. Blood was sampled for the measurement of quinapril and quinaprilat at 0, 0.5, 1, 1.5, 2, 3, 4, 6, 8, 12, 16 and 24 h. Milk was collected for measurement of quinapril and quinaprilat concentrations over the periods -4-0, 0-4, 4-8, 8-12, 12-18, 18-24 h. The areas under the plasma and milk concentration-time curves were estimated and an M/P ratio derived for both quinapril and quinaprilat. RESULTS: The M/P ratio for quinapril was 0.12 (95% CI 0.09,0.14). No quinapril was detected in milk after 4 h. No quinaprilat was detected in any of the milk samples. The estimated 'dose' of quinapril that would be received by the infant was 1.6% (95% CI 1.0,2.2) of the maternal dose, adjusted for respective weights. CONCLUSIONS: Quinapril appears to be 'safe' during breastfeeding according to conventional criteria, although as always, the risk:benefit ratio should be considered when it is to be given to a nursing mother. |
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Authors:
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E J Begg; R A Robson; S J Gardiner; L J Hudson; P A Reece; S C Olson; E L Posvar; A J Sedman |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 51 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-06-25 Completed Date: 2001-08-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 478-81 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, Christchurch School of Medicine, New Zealand. evan.begg@chmeds.ac.nz |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Angiotensin-Converting Enzyme Inhibitors / metabolism, pharmacokinetics Breast Feeding Female Humans Isoquinolines / blood, metabolism, pharmacokinetics* Middle Aged Milk, Human / chemistry, metabolism* Tetrahydroisoquinolines* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 82586-55-8/quinapril; 82768-85-2/quinaprilat |
| Comments/Corrections | |
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