| Quinapril in chronic heart failure. | |
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MedLine Citation:
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PMID: 2261147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Angiotensin converting enzyme inhibitors are now firmly established in the treatment of patients with chronic heart failure (CHF). Their beneficial acute and chronic hemodynamic effects are not associated with reflex tachycardia or drug tolerance. Angiotensin converting enzyme inhibitors produce symptomatic improvement and improve exercise capacity in all grades of heart failure. They also improve the prognosis of patients with severe heart failure. Quinapril is a recently introduced, nonsulfhydryl ACE inhibitor, whose intermediate half-life makes it well-suited for the treatment of patients with CHF. The acute and chronic hemodynamic effects of quinapril are similar to those of other ACE inhibitors. In a large, multicenter, randomized, placebo-controlled study of 225 patients with mild to moderate CHF, 10 to 40 mg/day quinapril significantly improved clinical status and exercise capacity in a dose-related manner. The incidence of side effects did not differ significantly from that of placebo. The initial studies with quinapril are promising and warrant further clinical investigation of this compound. |
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Authors:
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D B Northridge; H J Dargie |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Review |
Journal Detail:
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Title: American journal of hypertension Volume: 3 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 1990 Nov |
Date Detail:
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Created Date: 1991-02-07 Completed Date: 1991-02-07 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 283S-287S Citation Subset: IM |
Affiliation:
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Department of Cardiology, Western Infirmary, Glasgow, Scotland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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therapeutic use* Blood Pressure / drug effects Cardiac Output / drug effects Digoxin / therapeutic use Diuretics / therapeutic use Drug Therapy, Combination Heart Failure / drug therapy* Hemodynamics / drug effects* Humans Isoquinolines / pharmacokinetics, therapeutic use* Physical Exertion / drug effects Tetrahydroisoquinolines* Vascular Resistance / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors; 0/Diuretics; 0/Isoquinolines; 0/Tetrahydroisoquinolines; 20830-75-5/Digoxin; 82586-55-8/quinapril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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