Document Detail


Quinacrine mustard and nucleolar organizer region heteromorphisms in twins.
MedLine Citation:
PMID:  7199799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patterns of NOR activity in 640 metaphase spreads from twelve monozygotic (MZ) and eight dizygotic (DZ) twin pairs were studied to evaluate the heritability of this chromosomal heteromorphism. NORs were stained by a modification of the Ag-AS technique and counterstained with quinacrine mustard dihydrochloride to facilitate chromosome identification and assess their value in zygosity determination. In this study, all karyotypes were read blind with respect to zygosity and pair membership. A discriminant function analysis of pair score differences in MZ and DZ twins revealed that, in our sample, the probability of accurately determining zygosity with NOR scores was 0.93 and with QFQ scores was 0.99. We conclude that NOR and QFQ scores are highly heritable and of great value in zygosity determination. Data were collected from 687 metaphase spreads on the frequency with which an acrocentric chromosome was found in a satellite association. A significant correlation was found between this frequency and the degree of Ag-AS stain of the NOR. This study, therefore, confirms previous results showing that a high degree of NOR activity is found in those chromosomes most often involved in satellite associations.
Authors:
C C Morton; L A Corey; W E Nance; J A Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta geneticae medicae et gemellologiae     Volume:  30     ISSN:  0001-5660     ISO Abbreviation:  Acta Genet Med Gemellol (Roma)     Publication Date:  1981  
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370314     Medline TA:  Acta Genet Med Gemellol (Roma)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  39-49     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Child, Preschool
Chromosome Banding
Chromosomes, Human / ultrastructure*
Female
Humans
Male
Middle Aged
Nucleolus Organizer Region / ultrastructure*
Polymorphism, Genetic*
Pregnancy
Quinacrine Mustard
Twins*
Twins, Dizygotic*
Twins, Monozygotic*
Chemical
Reg. No./Substance:
4213-45-0/Quinacrine Mustard

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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