Document Detail

Quinacrine mustard and nucleolar organizer region heteromorphisms in twins.
MedLine Citation:
PMID:  7199799     Owner:  NLM     Status:  MEDLINE    
Patterns of NOR activity in 640 metaphase spreads from twelve monozygotic (MZ) and eight dizygotic (DZ) twin pairs were studied to evaluate the heritability of this chromosomal heteromorphism. NORs were stained by a modification of the Ag-AS technique and counterstained with quinacrine mustard dihydrochloride to facilitate chromosome identification and assess their value in zygosity determination. In this study, all karyotypes were read blind with respect to zygosity and pair membership. A discriminant function analysis of pair score differences in MZ and DZ twins revealed that, in our sample, the probability of accurately determining zygosity with NOR scores was 0.93 and with QFQ scores was 0.99. We conclude that NOR and QFQ scores are highly heritable and of great value in zygosity determination. Data were collected from 687 metaphase spreads on the frequency with which an acrocentric chromosome was found in a satellite association. A significant correlation was found between this frequency and the degree of Ag-AS stain of the NOR. This study, therefore, confirms previous results showing that a high degree of NOR activity is found in those chromosomes most often involved in satellite associations.
C C Morton; L A Corey; W E Nance; J A Brown
Related Documents :
7200459 - Genetic determination of nor activity in human lymphocytes from twins.
20882489 - Occurrence of natural triploidy in rhamdia quelen (siluriformes, heptapteridae).
2456279 - Harmine as a substitute for 33258 hoechst in the fpg technique.
3880379 - A direct technique for the preparation of chromosomes from early equine embryos.
6761099 - Immunofluorescent staining of human metaphase chromosomes with monoclonal antibody to h...
3377279 - Preliminary evidence for a fourth allele at the phosphohexose isomerase (phi) locus of ...
15768829 - Y chromosome polymorphisms in medicine.
12362469 - Strategies for continual application of marker-assisted selection in an open nucleus po...
23125359 - Plant sex chromosome evolution.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta geneticae medicae et gemellologiae     Volume:  30     ISSN:  0001-5660     ISO Abbreviation:  Acta Genet Med Gemellol (Roma)     Publication Date:  1981  
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370314     Medline TA:  Acta Genet Med Gemellol (Roma)     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  39-49     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Child, Preschool
Chromosome Banding
Chromosomes, Human / ultrastructure*
Middle Aged
Nucleolus Organizer Region / ultrastructure*
Polymorphism, Genetic*
Quinacrine Mustard
Twins, Dizygotic*
Twins, Monozygotic*
Reg. No./Substance:
4213-45-0/Quinacrine Mustard

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Low birth weight in twins versus singletons: separate entities and different implications for child ...
Next Document:  A genetic analysis of taste threshold for phenylthiocarbamide.