Document Detail

Quiescent gastric stem cells maintain the adult Drosophila stomach.
MedLine Citation:
PMID:  21984734     Owner:  NLM     Status:  MEDLINE    
The adult Drosophila copper cell region or "stomach" is a highly acidic compartment of the midgut with pH < 3. In this region, a specialized group of acid-secreting cells similar to mammalian gastric parietal cells has been identified by a unique ultrastructure and by copper-metallothionein fluorescence. However, the homeostatic mechanism maintaining the acid-secreting "copper cells" of the adult midgut has not been examined. Here, we combine cell lineage tracing and genetic analysis to investigate the mechanism by which the gastric epithelium is maintained. Our investigation shows that a molecularly identifiable population of multipotent, self-renewing gastric stem cells (GSSCs) produces the acid-secreting copper cells, interstitial cells, and enteroendocrine cells of the stomach. Our assays demonstrate that GSSCs are largely quiescent but can be induced to regenerate the gastric epithelium in response to environmental challenge. Finally, genetic analysis reveals that adult GSSC maintenance depends on Wnt signaling. Characterization of the GSSC lineage in Drosophila, with striking similarities to mammals, will advance the study of both homeostatic and pathogenic processes in the stomach.
Marie Strand; Craig A Micchelli
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-10-07
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  108     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-26     Completed Date:  2011-12-19     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17696-701     Citation Subset:  IM    
Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA.
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MeSH Terms
Cell Lineage
Gastric Mucosa / cytology*,  physiology
Gastrointestinal Tract / cytology*,  physiology*
Microscopy, Fluorescence
Multipotent Stem Cells / cytology*,  physiology
Signal Transduction / physiology*
Wnt Proteins
Reg. No./Substance:
0/Wnt Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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